Pathology Cancer cells compress intratumour vessels

The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and...

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Bibliographic Details
Published in:Nature 2004-02, Vol.427 (6976), p.695-695
Main Authors: Jain, Rakesh K, Padera, Timothy P, Stoll, Brian R, Tooredman, Jessica B, Capen, Diane, Tomaso, Emmanuelle di
Format: Article
Language:English
Subjects:
Animals
Cell Division
Diphtheria Toxin - pharmacology
Humans
Mice
Neoplasm Transplantation
Neoplasms - blood supply
Neoplasms - drug therapy
Neoplasms - pathology
Reperfusion
Transplantation, Heterologous
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Summary:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
ISSN:0028-0836
1476-4687
DOI:10.1038/427695a