The caveolar membrane system in endothelium: From cell signaling to vascular pathology

Caveolae are 50‐ to 100‐nm cholesterol and glycosphingolipid‐rich flask‐shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the reg...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2018-07, Vol.119 (7), p.5060-5071
Main Authors: Filippini, Antonio, Sica, Gigliola, D'Alessio, Alessio
Format: Article
Language:English
Subjects:
angiogenesis
Animals
cancer
Caveolae
Caveolae - metabolism
caveolin
Caveolins - metabolism
Cholesterol
Cholesterol - metabolism
Endothelial cells
Endothelium
Endothelium - metabolism
EPCs
Glycosphingolipids - metabolism
Humans
Invaginations
Organelles
Proteins
Scaffolding
Signal Transduction - physiology
Signaling
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Description
Summary:Caveolae are 50‐ to 100‐nm cholesterol and glycosphingolipid‐rich flask‐shaped invaginations commonly observed in many terminally differentiated cells. These organelles have been described in many cell types and are particularly abundant in endothelial cells, where they have been involved in the regulation of certain signaling pathways. Specific scaffolding proteins termed caveolins, along with the more recently discovered members of the cavin family, represent the major protein components during caveolae biogenesis. In addition, multiple studies aimed to investigate the expression and the regulation of these proteins significantly contributed to elucidate the role of caveolae and caveolins in endothelial cell physiology and disease. The aim of this review is to survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction. The contribution of the caveolar membrane network to endothelium.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.26793