Influence of the 6-month physical activity programs on renal function in obese boys

Background We intended to evaluate the effects of physical activity (PA) programs on renal function in obese boys. Methods Thirty-nine boys participated in one of the following three groups: soccer (SG, n =13), traditional PA (AG, n =13), and sedentary control (CG, n =13). SG and AG were involved in...

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Published in:Pediatric research 2018-05, Vol.83 (5), p.1011-1015
Main Authors: Lousa, Irina, Nascimento, Henrique, Rocha, Susana, Catarino, Cristina, Reis, Flávio, Rêgo, Carla, Santos-Silva, Alice, Seabra, André, Ribeiro, Sandra, Belo, Luís
Format: Article
Language:English
Subjects:
Adipose Tissue
Algorithms
Anthropometry
Biomarkers - blood
Body Composition
Body Mass Index
Boys
Child
clinical-investigation
Creatinine - blood
Cystatin C - blood
Exercise
Exercise Therapy
Glomerular Filtration Rate
Humans
Kidney - physiology
Kidney Function Tests
Kidneys
Male
Medicine
Medicine & Public Health
Nephrology
Obesity
Pediatric Obesity - therapy
Pediatric Surgery
Pediatrics
Sedentary Behavior
Soccer
Waist Circumference
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Summary:Background We intended to evaluate the effects of physical activity (PA) programs on renal function in obese boys. Methods Thirty-nine boys participated in one of the following three groups: soccer (SG, n =13), traditional PA (AG, n =13), and sedentary control (CG, n =13). SG and AG were involved in 6-month PA programs, involving three sessions/week for 60–90 min. Anthropometric measurements, body composition, creatinine and cystatin C plasmatic levels, and estimated glomerular filtration rate (eGFR) were evaluated. Results At baseline ( n =39), age and lean mass index (LMI) were positively correlated with creatinine levels. After 6 months, both intervention groups decreased the BMI z -score and waist circumference, while the CG increased the body fat percentage (BFP). LMI increased in all the groups. SG presented a small increment in plasma creatinine and a decrease in the eGFR values, using the Schwartz formula. Concerning the cystatin C levels and eGFR values using Filler (cystatin C-based) or Combined Zappitelli (creatinine/cystatin C-based) formulas, no significant changes were observed in any group. Conclusion The combined Zappitelli formula showed no significant impact of PA on eGFR in obese boys. Although plasma creatinine is significantly influenced by lean body mass, cystatin C is likely to be a more accurate marker of renal function in this population.
ISSN:0031-3998
1530-0447
DOI:10.1038/pr.2018.15