Anti-inflammatory Activity of a New Sphingosine Derivative and Cembrenoid Diterpene (Lobohedleolide) Isolated from Marine Soft Corals of Sinularia crassa TIXIER-DURIVAULT and Lobophytum species of the Andaman and Nicobar Islands

The aim of this study is to determine the anti-inflammatory activity of a new sphingosine derivative (1) and cembrenoid diterpene (lobohedleolide) (2) isolated from the soft corals of Sinularia crassa and Lobophytum species respectively, collected on the coasts of Andaman and Nicobar Islands. The an...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(7), pp.1311-1313
Main Authors: Radhika, Parvataneni, Rao, Pragada Rajeswara, Archana, Jorige, Rao, Nalamolu Koteswara
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Bridged Bicyclo Compounds - isolation & purification
Bridged Bicyclo Compounds - pharmacology
carrageenin edema
cembrenoid diterpene
cotton pellet granuloma
Female
Furans - isolation & purification
Furans - pharmacology
Lobophytum
Lobophytum sp
Male
Rats
Rats, Sprague-Dawley
Sinularia
Sinularia crassa
Species Specificity
Spectrum Analysis - methods
sphingosine derivative
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Summary:The aim of this study is to determine the anti-inflammatory activity of a new sphingosine derivative (1) and cembrenoid diterpene (lobohedleolide) (2) isolated from the soft corals of Sinularia crassa and Lobophytum species respectively, collected on the coasts of Andaman and Nicobar Islands. The anti-inflammatory activity was evaluated using carrageenin-induced rat hind paw edema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. Indomethacin was used as a standard drug in this study. Both the sphingosine derivative (1) and the cembrenoid diterpene (2) produced the maximum effect at a dose of 10 mg/kg and this is comparable to that of indomethacin (2 mg/kg, p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.1311