Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli

The inhibition of superoxide production by human neutrophils has been used to screen New Zealand's unique biota for anti-inflammatory natural products. Bioactivity-directed isolation on an extract of the sponge Dysidea cf. cristagalli led to a new sesquiterpene-quinone (4) with anti-inflammator...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-09, Vol.68 (9), p.1431-1433
Main Authors: McNamara, Catherine E, Larsen, Lesley, Perry, Nigel B, Harper, Jacquie L, Berridge, Michael V, Chia, Elizabeth W, Kelly, Michelle, Webb, Victoria L
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Dysidea
Dysidea - chemistry
Dysidea cristagalli
Humans
Inhibitory Concentration 50
Molecular Structure
Neutrophils - drug effects
New Zealand
Quinones - chemistry
Quinones - isolation & purification
Quinones - pharmacology
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Superoxides - metabolism
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The inhibition of superoxide production by human neutrophils has been used to screen New Zealand's unique biota for anti-inflammatory natural products. Bioactivity-directed isolation on an extract of the sponge Dysidea cf. cristagalli led to a new sesquiterpene-quinone (4) with anti-inflammatory activity, plus acetylated hydroquinone (3). These compounds inhibited superoxide production in vitro with IC50's of 3 microM (3) and 11 microM (4).
ISSN:0163-3864
DOI:10.1021/np050171n