Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia

ABSTRACTLeukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10‐year‐old female patient presented with a 1‐month history of an asymptomatic, firm, and pinkish‐red...

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Bibliographic Details
Published in:Special care in dentistry 2018-05, Vol.38 (3), p.160-162
Main Authors: Fernandes, Karin Sá, Gallottini, Marina, Castro, Talita, Amato, Mauricio Flamínio, Lago, Juvani Saturno, Braz‐Silva, Paulo Henrique
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Biopsy
Bone marrow
Bone resorption
Chemotherapy
Dentistry
Gingiva
gingival enlargement
gingival leukemic infiltration
gingival overgrowth
Leukemia
Myeloid leukemia
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Summary:ABSTRACTLeukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10‐year‐old female patient presented with a 1‐month history of an asymptomatic, firm, and pinkish‐red generalized gingival overgrowth. There was no bone resorption. Incisional biopsy of the gingival tissue was performed, with histopathological examination revealing a diffuse and hypercellular infiltration of monocytoid cells. The patient was referred to a hematologist and underwent a bone marrow biopsy, which led to a conclusive diagnosis of acute myeloid leukemia. The patient was treated with chemotherapy and we observed regression of gingival enlargement after 4 weeks from the initial therapy.
ISSN:0275-1879
1754-4505
DOI:10.1111/scd.12283