The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms

Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty pregnant women with GDM and 40 healthy pregnant women were included in the stud...

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Bibliographic Details
Published in:Gynecological endocrinology 2018-10, Vol.34 (10), p.849-852
Main Authors: Akbaba, Gulhan, Akbaba, Eren, Sahin, Cem, Kara, Murat
Format: Article
Language:English
Subjects:
Adult
Alleles
Blood Glucose
Case-Control Studies
Diabetes, Gestational - blood
Diabetes, Gestational - genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Gestational diabetes mellitus
Humans
Insulin Resistance - genetics
Polymorphism, Single Nucleotide
Pregnancy
selenoprotein P (SEPP1)
Selenoprotein P - genetics
single nucleotide polymorphism
Turkey
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Summary:Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty pregnant women with GDM and 40 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphisms (SNPs), specifically, rs4987017, rs13154178, rs146125471, rs28919926, and rs16872762 were studied. There was no difference between the groups in terms of polymorphism rs146125471, rs28919926, or rs16872762 (p > .05). There was a significant difference in SNP rs13154178 polymorphism between the two groups (p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2018.1460659