Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially...

Full description

Saved in:
Bibliographic Details
Published in:Science translational medicine 2018-04, Vol.10 (436)
Main Authors: Chabannon, Christian, Kuball, Jurgen, Bondanza, Attilio, Dazzi, Francesco, Pedrazzoli, Paolo, Toubert, Antoine, Ruggeri, Annalisa, Fleischhauer, Katharina, Bonini, Chiara
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.aap9630