Successful treatment of antisynthetase syndrome presenting as rhabdomyolysis with rituximab

Rhabdomyolysis is a syndrome of muscle necrosis with subsequent release of intracellular content into the blood. There are various causes for rhabdomyolysis that include trauma, medications and rarely autoimmune conditions such as autoimmune myositis. Antisynthetase syndrome is an autoimmune conditi...

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Bibliographic Details
Published in:Rheumatology international 2018-06, Vol.38 (6), p.1125-1130
Main Authors: Sabha, Marwa Mohammed, Simo, Hermann Talom, Shadid, Rana Mohammed, Altorok, Nezam Ibrahim
Format: Article
Language:English
Subjects:
Adult
Case Based Review
Health risk assessment
Humans
Immunotherapy
Male
Medicine
Medicine & Public Health
Monoclonal antibodies
Myositis - drug therapy
Retrospective Studies
Rhabdomyolysis - drug therapy
Rheumatology
Rituximab - therapeutic use
Treatment Outcome
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Summary:Rhabdomyolysis is a syndrome of muscle necrosis with subsequent release of intracellular content into the blood. There are various causes for rhabdomyolysis that include trauma, medications and rarely autoimmune conditions such as autoimmune myositis. Antisynthetase syndrome is an autoimmune condition characterized by positive antisynthetase antibody, myopathy, lung disease and arthritis. To our knowledge, rhabdomyolysis in antisynthetase syndrome has not been reported in the literature. In this report, we present a patient who presented with features of rhabdomyolysis and was diagnosed with antisynthetase syndrome. This patient was treated with systemic steroids with partial improvement, followed by rituximab, which led to significant improvement in his condition. In addition, we summarize all cases reported in the literature of inflammatory myopathy-associated rhabdomyolysis.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-018-4025-1