Relationship between induced sputum cytology and inflammatory status with lung structural and functional abnormalities in asbestosis

Background Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression in these patients. Methods Thirty‐nine ex‐workers with asbestosis on high‐resol...

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Bibliographic Details
Published in:American journal of industrial medicine 2008-03, Vol.51 (3), p.186-194
Main Authors: Setta, José Henrique, Neder, José Alberto, Bagatin, Ericson, Terra-Filho, Mario, Nápolis, Lara Maris, Corso, Simone Dal, Amorin, Maria Marta Ferreira, Rodrigues, Reynaldo Tavares, Fernandes, Ana Luísa Godoy, Nery, Luiz Eduardo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
asbestosis
Asbestosis - blood
Asbestosis - diagnostic imaging
Asbestosis - immunology
Asbestosis - physiopathology
Biological and medical sciences
Brazil
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
cytokines
Humans
induced sputum
inflammation
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Interleukin-8 - analysis
Interleukin-8 - blood
Interviews as Topic
Lung - pathology
Lung - physiopathology
Lung Volume Measurements
Male
Medical sciences
Middle Aged
pulmonary function
Spirometry
Sputum - cytology
Sputum - immunology
Tomography, X-Ray Computed - methods
Toxicology
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Summary:Background Asbestosis is associated with lung cellular and immunological abnormalities. Induced sputum cytology and local and systemic markers of inflammation may be helpful to characterize disease status and progression in these patients. Methods Thirty‐nine ex‐workers with asbestosis on high‐resolution CT (HRCT) and 21 non‐exposed controls were evaluated. Sputum cytology and IL‐8 in serum and sputum were related to lung function impairment. Results Subjects with asbestosis had reduced sputum cellularity but higher macrophage/neutrophil ratio and % macrophage as compared with controls. Sputum and serum IL‐8 were also higher in patients with asbestosis (P 
ISSN:0271-3586
1097-0274
DOI:10.1002/ajim.20546