The detection of synergy between meropenem and polymyxin B against meropenem-resistant Acinetobacter baumannii using Etest® and time-kill assay

Abstract Time-kill assay and Etest testing for synergy of meropenem (MER) (1× MIC) plus polymyxin B (1/4, 1/2, and 1× MIC) were performed against 8 genetically unique MER-resistant clinical Acinetobacter baumannii isolates. Time-kill assay demonstrated synergy for all isolates, whereas Etest showed...

Full description

Saved in:
Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2009-02, Vol.63 (2), p.228-232
Main Authors: Pankey, George A, Ashcraft, Deborah S
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter Infections - microbiology
Anti-Bacterial Agents - pharmacology
Bacteriology
Biological and medical sciences
Clinical Laboratory Techniques
Colony Count, Microbial - methods
Drug Resistance, Bacterial - genetics
Drug Resistance, Bacterial - physiology
Drug Synergism
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Medical sciences
Meropenem
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Polymyxin B
Polymyxin B - pharmacology
Synergy
Thienamycins - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Time-kill assay and Etest testing for synergy of meropenem (MER) (1× MIC) plus polymyxin B (1/4, 1/2, and 1× MIC) were performed against 8 genetically unique MER-resistant clinical Acinetobacter baumannii isolates. Time-kill assay demonstrated synergy for all isolates, whereas Etest showed synergy in 5 isolates and indifference in 3.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2008.11.002