Three-Component Site-Selective Synthesis of Highly Substituted 5 H -Chromeno-[4,3- b ]pyridines

An efficient and concise one-pot procedure was developed based on a cascade reaction of 3-formylchromones 1 and different types of 1,1-enediamines (EDAMs) 2 with different alcohols or amines 3 by a site-selective synthesis of 5 H-chromeno[4,3- b]pyridines in an environmentally friendly solvent. This...

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Published in:Journal of organic chemistry 2018-05, Vol.83 (9), p.4981-4989
Main Authors: Zhang, Cong-Hai, Huang, Rong, Hu, Xing-Mei, Lin, Jun, Yan, Sheng-Jiao
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Language:English
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container_issue 9
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container_title Journal of organic chemistry
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creator Zhang, Cong-Hai
Huang, Rong
Hu, Xing-Mei
Lin, Jun
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description An efficient and concise one-pot procedure was developed based on a cascade reaction of 3-formylchromones 1 and different types of 1,1-enediamines (EDAMs) 2 with different alcohols or amines 3 by a site-selective synthesis of 5 H-chromeno[4,3- b]pyridines in an environmentally friendly solvent. This protocol is especially suitable for the efficient and rapid parallel synthesis of 5 H-chromeno[4,3- b]pyridine compounds. It also has some advantages, such as convenience of operation, short reaction times, use of a green solvent, and ease of purification by washing the crude products with ethanol.
doi_str_mv 10.1021/acs.joc.8b00099
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title Three-Component Site-Selective Synthesis of Highly Substituted 5 H -Chromeno-[4,3- b ]pyridines
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