Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

• Published in: Liver international 2018-11, Vol.38 (11), p.1930-1939
• Main Authors: Wu, Daxian, Rao, Qunfang, Chen, Wenqian, Ji, Feiyang, Xie, Zhongyang, Huang, Kaizhou, Chen, Er'mei, Zhao, Yalei, Ouyang, Xiaoxi, Zhang, Sainan, Jiang, Zhengyi, Zhang, Lingjian, Xu, Linjie, Gao, Hainv, Li, Lanjuan
• Format: Article
• Language: English
• Subjects: Adult; Aspartate transaminase; Biopsy; Cholinesterase; chronic hepatitis B; Cirrhosis; Cross-Sectional Studies; Diagnosis; Diagnostic systems; Female; Fibrosis; free tetraiodothyronine; Hepatitis; Hepatitis B; Hepatitis B, Chronic - complications; Hormones; Humans; Interferon; Liver; Liver - pathology; liver biopsy; Liver cirrhosis; Liver Cirrhosis - diagnosis; Liver Cirrhosis - pathology; liver fibrosis; Male; Middle Aged; Patients; Platelets; ROC Curve; Severity of Illness Index; Thyroid; Thyroid Function Tests; Thyroid hormones; Thyroxine - blood; Transaminase; Young Adult; γ-Glutamyltransferase
• ISSN: 1478-3223; 1478-3231
• DOI: 10.1111/liv.13756

Background & Aims Non‐invasive assessment methods for liver fibrosis are urgently needed. The present study aimed to develop a novel diagnostic model for fibrosis staging in patients with chronic hepatitis B. Methods A cross‐sectional set of 417 chronic hepatitis B patients who underwent liver biopsy was enrolled and the METAVIR score was adopted as the reference of fibrosis staging. Results Among thyroid hormones, only the level of free tetraiodothyronine (FT4) decreased gradually with the METAVIR fibrosis score (P