Potential role of extracellular vesicle–mediated antigen presentation in Helicobacter pylori hypersensitivity during eradication therapy

[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induc...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2018-08, Vol.142 (2), p.672-676.e12
Main Authors: Ito, Takamasa, Shiromizu, Takashi, Ohnishi, Shunsuke, Suzuki, Shotaro, Mabe, Katsuhiro, Hasegawa, Akito, Ujiie, Hideyuki, Fujita, Yasuyuki, Sato, Yuichi, Terai, Shuji, Kato, Mototsugu, Asaka, Masahiro, Tomonaga, Takeshi, Shimizu, Hiroshi, Abe, Riichiro
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antigen Presentation
Antigens, Bacterial - immunology
Cells, Cultured
Cytokines
Dehydrogenases
Dendritic Cells - immunology
Deoxyribonucleic acid
DNA
DNA polymerase
Drug Therapy, Combination
Enzyme-Linked Immunospot Assay
Extracellular Vesicles - immunology
Female
Gastric cancer
Helicobacter Infections - complications
Helicobacter Infections - drug therapy
Helicobacter Infections - immunology
Helicobacter pylori - physiology
Humans
Hypersensitivity
Hypersensitivity - complications
Hypersensitivity - immunology
Interferon-gamma - metabolism
Leukocytes, Mononuclear - immunology
Lymphocytes
Male
Middle Aged
Patients
Proteins
Proton Pump Inhibitors - therapeutic use
Skin
Skin - pathology
Stomach Neoplasms - etiology
Stomach Neoplasms - prevention & control
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Description
Summary:[...]we consider that H pylori components are required to invade the body to induce an immune reaction against H pylori. [...]even if H pylori components invade the body, they would be rapidly degraded by enzymes. [...]we used EVs from patients' sera; however, the EVs did not successfully induce an immune reaction, as determined by using flow cytometric analysis of CD154+ H pylori–specific T cells. [...]it would be possible to reattempt or resume H pylori eradication therapy when skin eruptions develop because drug eruptions could be ruled out. [...]H pylori components in EVs can induce skin manifestations during antibiotic treatment.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2018.02.046