Association between intra- and post-arrest hyperoxia on mortality in adults with cardiac arrest: A systematic review and meta-analysis

The association between intra-arrest and post-arrest hyperoxia and mortality in adults with cardiac arrest (CA) is widely debated. We therefore conducted a systematic review and meta-analysis to investigate the association between intra-arrest and post-arrest hyperoxia and mortality in adults with C...

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Bibliographic Details
Published in:Resuscitation 2018-06, Vol.127, p.83-88
Main Authors: Patel, Jignesh K., Kataya, Abdo, Parikh, Puja B.
Format: Article
Language:English
Subjects:
Adult
Cardiac arrest
Cardiopulmonary Resuscitation
Heart Arrest - complications
Heart Arrest - mortality
Heart Arrest - physiopathology
Humans
Hyperoxemia
Hyperoxia
Hyperoxia - complications
Hyperoxia - mortality
Hyperoxia - physiopathology
Mortality
Observational Studies as Topic
Odds Ratio
Retrospective Studies
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Summary:The association between intra-arrest and post-arrest hyperoxia and mortality in adults with cardiac arrest (CA) is widely debated. We therefore conducted a systematic review and meta-analysis to investigate the association between intra-arrest and post-arrest hyperoxia and mortality in adults with CA. We systematically searched MEDLINE and Cochrane databases to identify observational studies from January 2008 to December 2017 investigating the relationship between hyperoxia (either intra-arrest or post-arrest) and mortality in adults with CA. We included 16 observational studies with a total of 40,573 adult patients. Six studies included patients only with out-of-hospital CA (OHCA), 2 studies included patients only with in-hospital CA (IHCA), and 8 studies included patients with both OHCA and IHCA. Two studies assessed intra-arrest hyperoxia while 14 studies examined post-arrest hyperoxia. Of the 10 studies included for quantitative analysis, intra-arrest hyperoxia was associated with a significantly lower mortality rate [odds ratio (OR) 0.25, 95% confidence interval (CI) 0.12–0.53, p 
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2018.04.008