Saikosaponin a Inhibits Cigarette Smoke-Induced Oxidant Stress and Inflammatory Responses by Activation of Nrf2

Saikosaponin a (SSa), a triterpenoid saponin, has numerous pharmacological properties, including anti-inflammatory and antioxidant effects. The purpose of this study was to investigate whether and how SSa protected against cigarette smoke (CS)-induced lung inflammation in mice. The mice were exposed...

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Bibliographic Details
Published in:Inflammation 2018-08, Vol.41 (4), p.1297-1303
Main Authors: Chen, Ru-jie, Guo, Xian-yang, Cheng, Bi-huan, Gong, Yu-qiang, Ying, Bin-yu, Lin, Meng-xiang
Format: Article
Language:English
Subjects:
Antioxidants
Biomedical and Life Sciences
Biomedicine
Cigarette smoke
IL-1β
Immunology
Inflammation
Internal Medicine
Lungs
NF-κB protein
Original Article
Pathology
Pharmacology/Toxicology
Rheumatology
Tobacco smoke
Tumor necrosis factor-α
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Summary:Saikosaponin a (SSa), a triterpenoid saponin, has numerous pharmacological properties, including anti-inflammatory and antioxidant effects. The purpose of this study was to investigate whether and how SSa protected against cigarette smoke (CS)-induced lung inflammation in mice. The mice were exposed to CS and SSa was administered by an intraperitoneal (i.p.) injection 1 h before CS treatment for 5 consecutive days. The results showed that SSa significantly inhibited CS-induced inflammatory cell infiltration, NO, TNF-α, and IL-1β production in BALF. SSa also inhibited CS-induced MPO and MDA contents in lung tissues. Furthermore, SSa significantly inhibited CS-induced NF-κB and upregulated the expression of Nrf2 and HO-1. In conclusion, these results support a therapeutic potential for SSa in CS-induced lung inflammation.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-018-0778-7