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A Guide to IL‐1 family cytokines in adjuvanticity
Growing awareness of the multiplicity of roles for the IL‐1 family in immune regulation has prompted research exploring these cytokines in the context of vaccine‐induced immunity. While tightly regulated, cytokines of the IL‐1 family are normally released in response to cellular stress and in combin...
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Published in: | The FEBS journal 2018-07, Vol.285 (13), p.2377-2401 |
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description | Growing awareness of the multiplicity of roles for the IL‐1 family in immune regulation has prompted research exploring these cytokines in the context of vaccine‐induced immunity. While tightly regulated, cytokines of the IL‐1 family are normally released in response to cellular stress and in combination with other danger‐/damage‐associated molecular patterns (DAMPs), triggering potent local and systemic immune responses. In the context of infection or autoimmunity, engagement of IL‐1 family receptors links robust innate responses to adaptive immunity. Clinical and experimental evidence has revealed that many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members in response to adjuvant‐induced damage or cell death may be a determining factor in the transition from local inflammation to the induction of an adaptive response. Here, we analyse the effects of IL‐1 family cytokines on innate and adaptive immunity with a particular emphasis on activation of antigen‐presenting cells and induction of T cell‐mediated immunity, and we address in detail the contribution of these cytokines to the modes of action of vaccine adjuvants including those currently approved for human use.
Many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members and damage‐/danger‐associated molecular patterns (DAMPs) induced by the adjuvant may act as a decisive factor in the transition from local inflammation to the induction of adaptive responses. This review explores the role of IL‐1 family cytokines in the mode of action of adjuvants in clinical and preclinical use. |
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Many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members and damage‐/danger‐associated molecular patterns (DAMPs) induced by the adjuvant may act as a decisive factor in the transition from local inflammation to the induction of adaptive responses. This review explores the role of IL‐1 family cytokines in the mode of action of adjuvants in clinical and preclinical use.</description><identifier>ISSN: 1742-464X</identifier><identifier>EISSN: 1742-4658</identifier><identifier>DOI: 10.1111/febs.14467</identifier><identifier>PMID: 29656546</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adaptive immunity ; Adjuvanticity ; Adjuvants ; Antigen-presenting cells ; Autoimmunity ; Cell activation ; Cell death ; Cellular stress response ; cell‐mediated immunity ; Cytokines ; Damage patterns ; Hazards ; Immune response ; Immunity ; Immunoregulation ; inflammasome ; interleukin‐1 family ; Lymphocytes ; Lymphocytes T ; Molecular chains ; NLRP3 ; Receptors ; vaccine ; Vaccines</subject><ispartof>The FEBS journal, 2018-07, Vol.285 (13), p.2377-2401</ispartof><rights>2018 Federation of European Biochemical Societies</rights><rights>2018 Federation of European Biochemical Societies.</rights><rights>Copyright © 2018 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4597-e2b98b7dc49a980ae9e4c3a16088d1cff84c17b3857f57665bc1863d098cc9393</citedby><cites>FETCH-LOGICAL-c4597-e2b98b7dc49a980ae9e4c3a16088d1cff84c17b3857f57665bc1863d098cc9393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29656546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muñoz‐Wolf, Natalia</creatorcontrib><creatorcontrib>Lavelle, Ed C.</creatorcontrib><title>A Guide to IL‐1 family cytokines in adjuvanticity</title><title>The FEBS journal</title><addtitle>FEBS J</addtitle><description>Growing awareness of the multiplicity of roles for the IL‐1 family in immune regulation has prompted research exploring these cytokines in the context of vaccine‐induced immunity. While tightly regulated, cytokines of the IL‐1 family are normally released in response to cellular stress and in combination with other danger‐/damage‐associated molecular patterns (DAMPs), triggering potent local and systemic immune responses. In the context of infection or autoimmunity, engagement of IL‐1 family receptors links robust innate responses to adaptive immunity. Clinical and experimental evidence has revealed that many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members in response to adjuvant‐induced damage or cell death may be a determining factor in the transition from local inflammation to the induction of an adaptive response. Here, we analyse the effects of IL‐1 family cytokines on innate and adaptive immunity with a particular emphasis on activation of antigen‐presenting cells and induction of T cell‐mediated immunity, and we address in detail the contribution of these cytokines to the modes of action of vaccine adjuvants including those currently approved for human use.
Many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members and damage‐/danger‐associated molecular patterns (DAMPs) induced by the adjuvant may act as a decisive factor in the transition from local inflammation to the induction of adaptive responses. This review explores the role of IL‐1 family cytokines in the mode of action of adjuvants in clinical and preclinical use.</description><subject>Adaptive immunity</subject><subject>Adjuvanticity</subject><subject>Adjuvants</subject><subject>Antigen-presenting cells</subject><subject>Autoimmunity</subject><subject>Cell activation</subject><subject>Cell death</subject><subject>Cellular stress response</subject><subject>cell‐mediated immunity</subject><subject>Cytokines</subject><subject>Damage patterns</subject><subject>Hazards</subject><subject>Immune response</subject><subject>Immunity</subject><subject>Immunoregulation</subject><subject>inflammasome</subject><subject>interleukin‐1 family</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Molecular chains</subject><subject>NLRP3</subject><subject>Receptors</subject><subject>vaccine</subject><subject>Vaccines</subject><issn>1742-464X</issn><issn>1742-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKw0AUhgdRbK1ufAAJuBEhdSaZ67KWthYKLlRwN0wmE5iaS80kSnY-gs_okzg1tQsXns05i4-f838AnCM4Rn5uMpO4McKYsgMwRAxHIaaEH-5v_DwAJ86tIYwJFuIYDCJBCSWYDkE8CRatTU3QVMFy9fXxiYJMFTbvAt011YstjQtsGah03b6psrHaNt0pOMpU7szZbo_A03z2OL0LV_eL5XSyCjUmgoUmSgRPWKqxUIJDZYTBOlaIQs5TpLOMY41YEnPCMsIoJYlGnMYpFFxrEYt4BK763E1dvbbGNbKwTps8V6WpWicjGBHmm_heI3D5B11XbV367zxFacyhL-yp657SdeVcbTK5qW2h6k4iKLcq5Val_FHp4YtdZJsUJt2jv-48gHrg3eam-ydKzme3D33oN7OFfIk</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Muñoz‐Wolf, Natalia</creator><creator>Lavelle, Ed C.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>A Guide to IL‐1 family cytokines in adjuvanticity</title><author>Muñoz‐Wolf, Natalia ; Lavelle, Ed C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4597-e2b98b7dc49a980ae9e4c3a16088d1cff84c17b3857f57665bc1863d098cc9393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adaptive immunity</topic><topic>Adjuvanticity</topic><topic>Adjuvants</topic><topic>Antigen-presenting cells</topic><topic>Autoimmunity</topic><topic>Cell activation</topic><topic>Cell death</topic><topic>Cellular stress response</topic><topic>cell‐mediated immunity</topic><topic>Cytokines</topic><topic>Damage patterns</topic><topic>Hazards</topic><topic>Immune response</topic><topic>Immunity</topic><topic>Immunoregulation</topic><topic>inflammasome</topic><topic>interleukin‐1 family</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Molecular chains</topic><topic>NLRP3</topic><topic>Receptors</topic><topic>vaccine</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muñoz‐Wolf, Natalia</creatorcontrib><creatorcontrib>Lavelle, Ed C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The FEBS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muñoz‐Wolf, Natalia</au><au>Lavelle, Ed C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Guide to IL‐1 family cytokines in adjuvanticity</atitle><jtitle>The FEBS journal</jtitle><addtitle>FEBS J</addtitle><date>2018-07</date><risdate>2018</risdate><volume>285</volume><issue>13</issue><spage>2377</spage><epage>2401</epage><pages>2377-2401</pages><issn>1742-464X</issn><eissn>1742-4658</eissn><abstract>Growing awareness of the multiplicity of roles for the IL‐1 family in immune regulation has prompted research exploring these cytokines in the context of vaccine‐induced immunity. 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Here, we analyse the effects of IL‐1 family cytokines on innate and adaptive immunity with a particular emphasis on activation of antigen‐presenting cells and induction of T cell‐mediated immunity, and we address in detail the contribution of these cytokines to the modes of action of vaccine adjuvants including those currently approved for human use.
Many vaccine adjuvants induce the release of one or multiple IL‐1 family cytokines. The coordinated release of IL‐1 family members and damage‐/danger‐associated molecular patterns (DAMPs) induced by the adjuvant may act as a decisive factor in the transition from local inflammation to the induction of adaptive responses. This review explores the role of IL‐1 family cytokines in the mode of action of adjuvants in clinical and preclinical use.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>29656546</pmid><doi>10.1111/febs.14467</doi><tpages>25</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adaptive immunity Adjuvanticity Adjuvants Antigen-presenting cells Autoimmunity Cell activation Cell death Cellular stress response cell‐mediated immunity Cytokines Damage patterns Hazards Immune response Immunity Immunoregulation inflammasome interleukin‐1 family Lymphocytes Lymphocytes T Molecular chains NLRP3 Receptors vaccine Vaccines |
title | A Guide to IL‐1 family cytokines in adjuvanticity |
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