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Byrsonima fagifolia: An integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action
Ethnopharmacological survey indicated leaves of Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders. The methanolic extract from the leaves of Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomo...
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| Published in: | Journal of ethnopharmacology 2008-11, Vol.120 (2), p.149-160 |
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| container_title | Journal of ethnopharmacology |
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| creator | Lima, Zeila Pinheiro dos Santos, Raquel de Cássia Torres, Talita Uliana Sannomiya, Miriam Rodrigues, Clenilson Martins dos Santos, Lourdes Campaner Pellizzon, Cláudia Helena Rocha, Lúcia Regina Machado Vilegas, Wagner Souza Brito, Alba Regina Monteiro Cardoso, Cássia Regina Primila Varanda, Eliana Aparecida de Moraes, Helen Pimenta Bauab, Taís Maria Carli, Camila Carlos, Iracilda Zeppone Hiruma-Lima, Clélia Akiko |
| description | Ethnopharmacological survey indicated leaves of
Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.
The methanolic extract from the leaves of
Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.
The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of
Escherichia coli,
Staphylococcus aureus and
Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.
Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action
in vitro.
Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments. |
| doi_str_mv | 10.1016/j.jep.2008.07.047 |
| format | article |
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Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.
The methanolic extract from the leaves of
Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.
The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of
Escherichia coli,
Staphylococcus aureus and
Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.
Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action
in vitro.
Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2008.07.047</identifier><identifier>PMID: 18761075</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject><![CDATA[animal disease models ; Animals ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - toxicity ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Anti-Ulcer Agents - toxicity ; Antidiarrheal action ; antidiarrheal effect ; Antidiarrheals - isolation & purification ; Antidiarrheals - pharmacology ; Antidiarrheals - toxicity ; antimicrobial properties ; antioxidant activity ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Antioxidants - toxicity ; Biological and medical sciences ; Brazil ; Byrsonima ; Byrsonima fagifolia ; chemical constituents of plants ; Disease Models, Animal ; Escherichia coli ; Free Radical Scavengers - isolation & purification ; Free Radical Scavengers - pharmacology ; Free Radical Scavengers - toxicity ; gastric mucosa ; General pharmacology ; Healing effect ; Helicobacter pylori ; Immunologic Factors - isolation & purification ; Immunologic Factors - pharmacology ; Immunologic Factors - toxicity ; immunomodulators ; inflammation ; leaves ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Male ; Malpighiaceae ; Malpighiaceae - chemistry ; Medical sciences ; medicinal plants ; medicinal properties ; Medicine, Traditional ; Mice ; Mutagenicity ; Mutagenicity Tests ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenolic compounds ; plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Plant Leaves ; protective effect ; Rats ; Rats, Wistar ; rodents ; Staphylococcus aureus ; Stomach Ulcer - drug therapy ; stomach ulcers ; Toxicity Tests ; traditional medicine]]></subject><ispartof>Journal of ethnopharmacology, 2008-11, Vol.120 (2), p.149-160</ispartof><rights>2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-22b5b07bf3c15e3ba719121b9b470fcb93a9707a3588280e33b42ae69f52e77c3</citedby><cites>FETCH-LOGICAL-c436t-22b5b07bf3c15e3ba719121b9b470fcb93a9707a3588280e33b42ae69f52e77c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20873720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18761075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Zeila Pinheiro</creatorcontrib><creatorcontrib>dos Santos, Raquel de Cássia</creatorcontrib><creatorcontrib>Torres, Talita Uliana</creatorcontrib><creatorcontrib>Sannomiya, Miriam</creatorcontrib><creatorcontrib>Rodrigues, Clenilson Martins</creatorcontrib><creatorcontrib>dos Santos, Lourdes Campaner</creatorcontrib><creatorcontrib>Pellizzon, Cláudia Helena</creatorcontrib><creatorcontrib>Rocha, Lúcia Regina Machado</creatorcontrib><creatorcontrib>Vilegas, Wagner</creatorcontrib><creatorcontrib>Souza Brito, Alba Regina Monteiro</creatorcontrib><creatorcontrib>Cardoso, Cássia Regina Primila</creatorcontrib><creatorcontrib>Varanda, Eliana Aparecida</creatorcontrib><creatorcontrib>de Moraes, Helen Pimenta</creatorcontrib><creatorcontrib>Bauab, Taís Maria</creatorcontrib><creatorcontrib>Carli, Camila</creatorcontrib><creatorcontrib>Carlos, Iracilda Zeppone</creatorcontrib><creatorcontrib>Hiruma-Lima, Clélia Akiko</creatorcontrib><title>Byrsonima fagifolia: An integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Ethnopharmacological survey indicated leaves of
Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.
The methanolic extract from the leaves of
Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.
The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of
Escherichia coli,
Staphylococcus aureus and
Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.
Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action
in vitro.
Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments.</description><subject>animal disease models</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Anti-Ulcer Agents - toxicity</subject><subject>Antidiarrheal action</subject><subject>antidiarrheal effect</subject><subject>Antidiarrheals - isolation & purification</subject><subject>Antidiarrheals - pharmacology</subject><subject>Antidiarrheals - toxicity</subject><subject>antimicrobial properties</subject><subject>antioxidant activity</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - toxicity</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Byrsonima</subject><subject>Byrsonima fagifolia</subject><subject>chemical constituents of plants</subject><subject>Disease Models, Animal</subject><subject>Escherichia coli</subject><subject>Free Radical Scavengers - isolation & purification</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free Radical Scavengers - toxicity</subject><subject>gastric mucosa</subject><subject>General pharmacology</subject><subject>Healing effect</subject><subject>Helicobacter pylori</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunologic Factors - toxicity</subject><subject>immunomodulators</subject><subject>inflammation</subject><subject>leaves</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Male</subject><subject>Malpighiaceae</subject><subject>Malpighiaceae - chemistry</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Medicine, Traditional</subject><subject>Mice</subject><subject>Mutagenicity</subject><subject>Mutagenicity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenolic compounds</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Leaves</subject><subject>protective effect</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>rodents</subject><subject>Staphylococcus aureus</subject><subject>Stomach Ulcer - drug therapy</subject><subject>stomach ulcers</subject><subject>Toxicity Tests</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhiMEokvhAbiAL3DqhrGdxAmcStUCUiUO0LM1cSapV0m82M5K-wI8N15lBTdO1tjfP_r1Octec8g58OrDLt_RPhcAdQ4qh0I9yTa8VmKrSiWfZhuQqt7WquAX2YsQdgCgeAHPs4sEVRxUucl-fz764GY7IetxsL0bLX5k1zOzc6TBY7QHYiEu3ZFFxw442g4jsfhIbMAQvdt7F8mcsCv2SOl9Hq4YztF2Fr0_3azjZI13rcUxTR2blogDzdYwTFk3v8ye9TgGenU-L7OHu9ufN1-399-_fLu5vt-aQlZxK0RbtqDaXhpekmxR8YYL3jZtoaA3bSOxUaBQlnUtaiAp20IgVU1fClLKyMvs_bo31f61UIh6ssHQOOJMbglagKikBJlAvoKpdQieer33SZI_ag76JF_vdJKvT_I1KJ3kp8yb8_Klnaj7lzjbTsC7M4DB4Nh7nI0NfzkBtZJKQOLerlyPTuPgE_PwQwCXwMtKQFMl4tNKUJJ1sOR1MJZmQ5316Td05-x_iv4BrGStQg</recordid><startdate>20081120</startdate><enddate>20081120</enddate><creator>Lima, Zeila Pinheiro</creator><creator>dos Santos, Raquel de Cássia</creator><creator>Torres, Talita Uliana</creator><creator>Sannomiya, Miriam</creator><creator>Rodrigues, Clenilson Martins</creator><creator>dos Santos, Lourdes Campaner</creator><creator>Pellizzon, Cláudia Helena</creator><creator>Rocha, Lúcia Regina Machado</creator><creator>Vilegas, Wagner</creator><creator>Souza Brito, Alba Regina Monteiro</creator><creator>Cardoso, Cássia Regina Primila</creator><creator>Varanda, Eliana Aparecida</creator><creator>de Moraes, Helen Pimenta</creator><creator>Bauab, Taís Maria</creator><creator>Carli, Camila</creator><creator>Carlos, Iracilda Zeppone</creator><creator>Hiruma-Lima, Clélia Akiko</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20081120</creationdate><title>Byrsonima fagifolia: An integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action</title><author>Lima, Zeila Pinheiro ; dos Santos, Raquel de Cássia ; Torres, Talita Uliana ; Sannomiya, Miriam ; Rodrigues, Clenilson Martins ; dos Santos, Lourdes Campaner ; Pellizzon, Cláudia Helena ; Rocha, Lúcia Regina Machado ; Vilegas, Wagner ; Souza Brito, Alba Regina Monteiro ; Cardoso, Cássia Regina Primila ; Varanda, Eliana Aparecida ; de Moraes, Helen Pimenta ; Bauab, Taís Maria ; Carli, Camila ; Carlos, Iracilda Zeppone ; Hiruma-Lima, Clélia Akiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-22b5b07bf3c15e3ba719121b9b470fcb93a9707a3588280e33b42ae69f52e77c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal disease models</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Anti-Ulcer Agents - toxicity</topic><topic>Antidiarrheal action</topic><topic>antidiarrheal effect</topic><topic>Antidiarrheals - isolation & purification</topic><topic>Antidiarrheals - pharmacology</topic><topic>Antidiarrheals - toxicity</topic><topic>antimicrobial properties</topic><topic>antioxidant activity</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - toxicity</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Byrsonima</topic><topic>Byrsonima fagifolia</topic><topic>chemical constituents of plants</topic><topic>Disease Models, Animal</topic><topic>Escherichia coli</topic><topic>Free Radical Scavengers - isolation & purification</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Free Radical Scavengers - toxicity</topic><topic>gastric mucosa</topic><topic>General pharmacology</topic><topic>Healing effect</topic><topic>Helicobacter pylori</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunologic Factors - toxicity</topic><topic>immunomodulators</topic><topic>inflammation</topic><topic>leaves</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Male</topic><topic>Malpighiaceae</topic><topic>Malpighiaceae - chemistry</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Medicine, Traditional</topic><topic>Mice</topic><topic>Mutagenicity</topic><topic>Mutagenicity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenolic compounds</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - toxicity</topic><topic>Plant Leaves</topic><topic>protective effect</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>rodents</topic><topic>Staphylococcus aureus</topic><topic>Stomach Ulcer - drug therapy</topic><topic>stomach ulcers</topic><topic>Toxicity Tests</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Zeila Pinheiro</creatorcontrib><creatorcontrib>dos Santos, Raquel de Cássia</creatorcontrib><creatorcontrib>Torres, Talita Uliana</creatorcontrib><creatorcontrib>Sannomiya, Miriam</creatorcontrib><creatorcontrib>Rodrigues, Clenilson Martins</creatorcontrib><creatorcontrib>dos Santos, Lourdes Campaner</creatorcontrib><creatorcontrib>Pellizzon, Cláudia Helena</creatorcontrib><creatorcontrib>Rocha, Lúcia Regina Machado</creatorcontrib><creatorcontrib>Vilegas, Wagner</creatorcontrib><creatorcontrib>Souza Brito, Alba Regina Monteiro</creatorcontrib><creatorcontrib>Cardoso, Cássia Regina Primila</creatorcontrib><creatorcontrib>Varanda, Eliana Aparecida</creatorcontrib><creatorcontrib>de Moraes, Helen Pimenta</creatorcontrib><creatorcontrib>Bauab, Taís Maria</creatorcontrib><creatorcontrib>Carli, Camila</creatorcontrib><creatorcontrib>Carlos, Iracilda Zeppone</creatorcontrib><creatorcontrib>Hiruma-Lima, Clélia Akiko</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Zeila Pinheiro</au><au>dos Santos, Raquel de Cássia</au><au>Torres, Talita Uliana</au><au>Sannomiya, Miriam</au><au>Rodrigues, Clenilson Martins</au><au>dos Santos, Lourdes Campaner</au><au>Pellizzon, Cláudia Helena</au><au>Rocha, Lúcia Regina Machado</au><au>Vilegas, Wagner</au><au>Souza Brito, Alba Regina Monteiro</au><au>Cardoso, Cássia Regina Primila</au><au>Varanda, Eliana Aparecida</au><au>de Moraes, Helen Pimenta</au><au>Bauab, Taís Maria</au><au>Carli, Camila</au><au>Carlos, Iracilda Zeppone</au><au>Hiruma-Lima, Clélia Akiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Byrsonima fagifolia: An integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-11-20</date><risdate>2008</risdate><volume>120</volume><issue>2</issue><spage>149</spage><epage>160</epage><pages>149-160</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Ethnopharmacological survey indicated leaves of
Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.
The methanolic extract from the leaves of
Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.
The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of
Escherichia coli,
Staphylococcus aureus and
Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.
Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action
in vitro.
Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18761075</pmid><doi>10.1016/j.jep.2008.07.047</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2008-11, Vol.120 (2), p.149-160 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20263303 |
| source | Elsevier |
| subjects | animal disease models Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - toxicity Antidiarrheal action antidiarrheal effect Antidiarrheals - isolation & purification Antidiarrheals - pharmacology Antidiarrheals - toxicity antimicrobial properties antioxidant activity Antioxidants - isolation & purification Antioxidants - pharmacology Antioxidants - toxicity Biological and medical sciences Brazil Byrsonima Byrsonima fagifolia chemical constituents of plants Disease Models, Animal Escherichia coli Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Free Radical Scavengers - toxicity gastric mucosa General pharmacology Healing effect Helicobacter pylori Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Immunologic Factors - toxicity immunomodulators inflammation leaves Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Malpighiaceae Malpighiaceae - chemistry Medical sciences medicinal plants medicinal properties Medicine, Traditional Mice Mutagenicity Mutagenicity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds plant extracts Plant Extracts - pharmacology Plant Extracts - toxicity Plant Leaves protective effect Rats Rats, Wistar rodents Staphylococcus aureus Stomach Ulcer - drug therapy stomach ulcers Toxicity Tests traditional medicine |
| title | Byrsonima fagifolia: An integrative study to validate the gastroprotective, healing, antidiarrheal, antimicrobial and mutagenic action |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T12%3A51%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Byrsonima%20fagifolia:%20An%20integrative%20study%20to%20validate%20the%20gastroprotective,%20healing,%20antidiarrheal,%20antimicrobial%20and%20mutagenic%20action&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Lima,%20Zeila%20Pinheiro&rft.date=2008-11-20&rft.volume=120&rft.issue=2&rft.spage=149&rft.epage=160&rft.pages=149-160&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/j.jep.2008.07.047&rft_dat=%3Cproquest_cross%3E20263303%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c436t-22b5b07bf3c15e3ba719121b9b470fcb93a9707a3588280e33b42ae69f52e77c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20263303&rft_id=info:pmid/18761075&rfr_iscdi=true |