Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway

Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, and targeting aerobic glycolysis becomes a promising therapeutic approach for cancer. Here we reported that a small polyphenol resveratrol exhibited profound anti‐tumor efficacy on...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2018-07, Vol.119 (7), p.6162-6172
Main Authors: Liu, Yu, Tong, Lin, Luo, Yan, Li, Xin, Chen, Gaowen, Wang, Yifeng
Format: Article
Language:English
Subjects:
Activation
AMPK
Anticancer properties
Apoptosis
Cancer
Caspase
Caspase-3
Cell proliferation
Enzyme inhibitors
Glycolysis
Kinases
Lactic acid
Liver
Liver cancer
Metastases
mTOR
Ovarian cancer
Resveratrol
Rewiring
Signal transduction
TOR protein
Xenografts
Xenotransplantation
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Summary:Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, and targeting aerobic glycolysis becomes a promising therapeutic approach for cancer. Here we reported that a small polyphenol resveratrol exhibited profound anti‐tumor efficacy on human ovarian cancer. Resveratrol markedly inhibited the proliferation, migration, and invasion of A2780 and SKOV3 ovarian cancer cells, while impaired glycolysis, and induced apoptosis in these cells. Exposure to resveratrol increased the expression and activation of AMPK and Caspase 3, and decreased the expression and activation of AMPK downstream kinase mTOR. Moreover, AMPK inhibitor Compound C significantly abolished the effects of resveratrol on the activation of AMPK and Caspase 3 and the inhibition of mTOR. In addition, in vivo data indicated that resveratrol suppressed ovarian cancer growth and liver metastasis in xenograft mouse model. In conclusion, our findings provide new insight into the mechanism underlying anticancer efficacy of resveratrol and help the utilization of resveratrol as a novel agent for the treatment of ovarian cancer. Resveratrol inhibited the proliferation, migration, and invasion of A2780 and SKOV3 ovarian cancer cells; resveratrol impaired glycolysis and induced apoptosis in ovarian cancer cells by activating AMPK/mTOR axis; resveratrol suppressed ovarian cancer growth and liver metastasis in xenograft mouse model.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.26822