Stromal cell networks coordinate immune response generation and maintenance

Summary Secondary lymphoid organs (SLO), including the spleen and lymph nodes (LN) are a meeting place for immune cells to initiate adaptive immune responses. Lymphocytes constantly circulate between SLO through the blood and lymph in search of their cognate antigen and are activated within the orga...

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Bibliographic Details
Published in:Immunological reviews 2018-05, Vol.283 (1), p.77-85
Main Authors: Alexandre, Yannick O., Mueller, Scott N.
Format: Article
Language:English
Subjects:
Adaptive immunity
Animals
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Communication - immunology
Computer architecture
fibroblastic reticular cells
Homeostasis
Humans
Immune response
immune responses
Immune system
Immune System - cytology
Immune System - immunology
Immune System - metabolism
Immunity
Immunologic Memory
Immunomodulation
Lymph nodes
Lymphocyte Activation - immunology
Lymphocytes
lymphoid stromal cells
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Lymphoid Tissue - metabolism
memory T cells
Mesenchyme
Organs
Spleen
Stromal cells
Stromal Cells - immunology
Stromal Cells - metabolism
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Summary Secondary lymphoid organs (SLO), including the spleen and lymph nodes (LN) are a meeting place for immune cells to initiate adaptive immune responses. Lymphocytes constantly circulate between SLO through the blood and lymph in search of their cognate antigen and are activated within the organized microarchitecture of SLO. Lymphoid stromal cells (LSC) of mesenchymal and endothelial origin construct and support the microarchitecture of SLO by defining distinct compartments and providing signals that can either promote or inhibit immune responses. Here, we discuss recent studies indicating that LSC, including fibroblastic reticular cells (FRC), contribute substantially to immune responses and may tune responses to secondary challenge.
ISSN:0105-2896
1600-065X
DOI:10.1111/imr.12641