Impact of Different Perfusion Modalities on Coronary and Carotid Blood Flow Velocities in an Adult ECLS Swine Model

The objective of this study was to compare the effects of nonpulsatile and ECG‐synchronized pulsatile extracorporeal life support on coronary and carotid blood flow velocities using transthoracic echocardiography and vascular ultrasound, respectively. Nine adult swine were randomly separated into no...

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Bibliographic Details
Published in:Artificial organs 2018-09, Vol.42 (9), p.918-921
Main Authors: Wang, Shigang, Patel, Sunil, Izer, Jenelle M., Clark, Joseph B., Kunselman, Allen R., Wilson, Ronald P., Ündar, Akif
Format: Article
Language:English
Subjects:
Animals
Arteries
Blood flow
Blood Flow Velocity - physiology
Blood Pressure - physiology
Carotid arteries
Carotid Arteries - physiology
Carotid artery
Carotid blood flow
Coronary artery
Coronary blood flow
Coronary vessels
Coronary Vessels - physiology
ECG synchronization
Echocardiography
EKG
Extracorporeal life support
Extracorporeal Membrane Oxygenation - methods
Hemodynamics - physiology
Livestock
Medical imaging
Models, Animal
Perfusion
Pulsatile flow
Pulsatile Flow - physiology
Regional Blood Flow - physiology
Swine
Swine model
Ultrasound
Vascular Resistance - physiology
Veins & arteries
Velocity
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Summary:The objective of this study was to compare the effects of nonpulsatile and ECG‐synchronized pulsatile extracorporeal life support on coronary and carotid blood flow velocities using transthoracic echocardiography and vascular ultrasound, respectively. Nine adult swine were randomly separated into nonpulsatile (NP, n = 5) and pulsatile (P, N = 4) groups and placed on ECLS for 24 h using an i‐cor ECLS system. Noninvasive transthoracic images of the left and right coronary artery and the left carotid artery were acquired at the pre‐ECLS (baseline), 30 min, 3, 6, 9, 12, and 24 h on‐ECLS stages. The mean diastolic velocity of the left and right coronary arteries in the NP group significantly decreased after 24 h on ECLS compared to the baseline and 30 min ECLS stages (P 
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.13141