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Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats
There are many plants in Mexico with medicinal properties, some of them used in alternative medicine to treat cancer, such is the case of Rhoeo discolor L. Hér Hance ( Commelinaceae family); however, there are not scientific reports that validate their antitumoral property. The present study shows t...
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| Published in: | Journal of ethnopharmacology 2008-02, Vol.115 (3), p.381-386 |
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| creator | Rosales-Reyes, Tábata de la Garza, Mireya Arias-Castro, Carlos Rodríguez-Mendiola, Martha Fattel-Fazenda, Samia Arce-Popoca, Evelia Hernández-García, Sergio Villa-Treviño, Saúl |
| description | There are many plants in Mexico with medicinal properties, some of them used in alternative medicine to treat cancer, such is the case of
Rhoeo discolor L. Hér Hance (
Commelinaceae family); however, there are not scientific reports that validate their antitumoral property. The present study shows the protective effects of the
Rhoeo discolor aqueous crude extract (ACE) against rat liver cancer using the resistant-hepatocyte model. The carcinogenesis protocol consisted on the initiation with
N-diethylnitrosamine, followed by the promotion with 2-acetylaminofluorene and a partial hepatectomy. After 24 days, the γ-glutamyl transpeptidase positive, corresponding to altered hepatocytes foci (AHF), were quantified. Additionally to discard a possible carcinogenic effect of ACE, it was first tested as promoting agent instead 2-acetylaminofluorene, and second, ACE was administered as initiator and promoter instead of the whole carcinogenic treatment. In summary, firstly, ACE administration reduced the number and area of preneoplastic lesions with dose below 20
mg/kg body weight and secondly, ACE administration neither presented a promoting or initiator effects nor induced the development of AHF. Results of this investigation justify continuing with further studies of
Rhoeo discolor components to develop chemoprevention strategies as an option in the treatment of cancer. |
| doi_str_mv | 10.1016/j.jep.2007.10.022 |
| format | article |
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Rhoeo discolor L. Hér Hance (
Commelinaceae family); however, there are not scientific reports that validate their antitumoral property. The present study shows the protective effects of the
Rhoeo discolor aqueous crude extract (ACE) against rat liver cancer using the resistant-hepatocyte model. The carcinogenesis protocol consisted on the initiation with
N-diethylnitrosamine, followed by the promotion with 2-acetylaminofluorene and a partial hepatectomy. After 24 days, the γ-glutamyl transpeptidase positive, corresponding to altered hepatocytes foci (AHF), were quantified. Additionally to discard a possible carcinogenic effect of ACE, it was first tested as promoting agent instead 2-acetylaminofluorene, and second, ACE was administered as initiator and promoter instead of the whole carcinogenic treatment. In summary, firstly, ACE administration reduced the number and area of preneoplastic lesions with dose below 20
mg/kg body weight and secondly, ACE administration neither presented a promoting or initiator effects nor induced the development of AHF. Results of this investigation justify continuing with further studies of
Rhoeo discolor components to develop chemoprevention strategies as an option in the treatment of cancer.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2007.10.022</identifier><identifier>PMID: 18063494</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>altered hepatocytes foci ; animal models ; Animals ; anticarcinogenic activity ; Biological and medical sciences ; chemoprevention ; Chemopreventive effect ; Commelinaceae ; Commelinaceae - chemistry ; Commelinaceae family ; dosage ; gamma-Glutamyltransferase - analysis ; General pharmacology ; Hepatocarcinogenesis ; hepatocytes ; Hormesis ; liver ; Liver - drug effects ; Liver - pathology ; liver neoplasms ; Liver Neoplasms, Experimental - prevention & control ; Male ; Medical sciences ; Medicinal plants ; medicinal properties ; Medicine, Traditional ; Mexico ; peptidases ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Precancerous Conditions - chemically induced ; Precancerous Conditions - drug therapy ; Purple maguey ; Rats ; Rats, Inbred F344 ; Rhoeo ; Rhoeo discolor ; Tradescantia ; traditional medicine</subject><ispartof>Journal of ethnopharmacology, 2008-02, Vol.115 (3), p.381-386</ispartof><rights>2007 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-4d35cbb7dfca1a1d5b31ed569f998790a0a2ea367e2a4c7b0e6a66b988da69863</citedby><cites>FETCH-LOGICAL-c436t-4d35cbb7dfca1a1d5b31ed569f998790a0a2ea367e2a4c7b0e6a66b988da69863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20005511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18063494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosales-Reyes, Tábata</creatorcontrib><creatorcontrib>de la Garza, Mireya</creatorcontrib><creatorcontrib>Arias-Castro, Carlos</creatorcontrib><creatorcontrib>Rodríguez-Mendiola, Martha</creatorcontrib><creatorcontrib>Fattel-Fazenda, Samia</creatorcontrib><creatorcontrib>Arce-Popoca, Evelia</creatorcontrib><creatorcontrib>Hernández-García, Sergio</creatorcontrib><creatorcontrib>Villa-Treviño, Saúl</creatorcontrib><title>Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>There are many plants in Mexico with medicinal properties, some of them used in alternative medicine to treat cancer, such is the case of
Rhoeo discolor L. Hér Hance (
Commelinaceae family); however, there are not scientific reports that validate their antitumoral property. The present study shows the protective effects of the
Rhoeo discolor aqueous crude extract (ACE) against rat liver cancer using the resistant-hepatocyte model. The carcinogenesis protocol consisted on the initiation with
N-diethylnitrosamine, followed by the promotion with 2-acetylaminofluorene and a partial hepatectomy. After 24 days, the γ-glutamyl transpeptidase positive, corresponding to altered hepatocytes foci (AHF), were quantified. Additionally to discard a possible carcinogenic effect of ACE, it was first tested as promoting agent instead 2-acetylaminofluorene, and second, ACE was administered as initiator and promoter instead of the whole carcinogenic treatment. In summary, firstly, ACE administration reduced the number and area of preneoplastic lesions with dose below 20
mg/kg body weight and secondly, ACE administration neither presented a promoting or initiator effects nor induced the development of AHF. Results of this investigation justify continuing with further studies of
Rhoeo discolor components to develop chemoprevention strategies as an option in the treatment of cancer.</description><subject>altered hepatocytes foci</subject><subject>animal models</subject><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>Biological and medical sciences</subject><subject>chemoprevention</subject><subject>Chemopreventive effect</subject><subject>Commelinaceae</subject><subject>Commelinaceae - chemistry</subject><subject>Commelinaceae family</subject><subject>dosage</subject><subject>gamma-Glutamyltransferase - analysis</subject><subject>General pharmacology</subject><subject>Hepatocarcinogenesis</subject><subject>hepatocytes</subject><subject>Hormesis</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>liver neoplasms</subject><subject>Liver Neoplasms, Experimental - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicinal plants</subject><subject>medicinal properties</subject><subject>Medicine, Traditional</subject><subject>Mexico</subject><subject>peptidases</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Precancerous Conditions - chemically induced</subject><subject>Precancerous Conditions - drug therapy</subject><subject>Purple maguey</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rhoeo</subject><subject>Rhoeo discolor</subject><subject>Tradescantia</subject><subject>traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi0EokvhB3ABX-DULHbi2Ik4VRVfUhES0LM1sSfUq2wcbG9VTvx1JtoV3DhZtp555fcZxp5LsZVC6je77Q6XbS2EoftW1PUDtpGdqSvTmuYh24jGdFVnlDxjT3LeCQKlEo_ZmeyEblSvNuz35c8DxkPmLh08crwvCVzhceRfbyNG7kN2cYrpggP_jPfBwcz36IMLM0x8mWAuF9yjSwgZMy-3yMeY9lBCnNeUKdxh4kvCGSPRuQRHgAs8zDxByU_ZoxGmjM9O5zm7ef_u-9XH6vrLh09Xl9eVU40ulfJN64bB-NGBBOnboZHoW92Pfd-ZXoCAGqHRBmtQzgwCNWg99F3nQfedbs7Z62PukiI1zsXuqRlOVGCtb2tRa6VaRaA8gi7FnBOOdklhD-mXlcKu1u3OknW7Wl-fyDrNvDiFHwaS82_ipJmAVycAsoNpTDC7kP9ylCXaVkriXh65EaKFH4mYm2-1kI0Q1EG3LRFvjwSSrLuAyWYXcHa0koSuWB_Dfz76B43uqnw</recordid><startdate>20080212</startdate><enddate>20080212</enddate><creator>Rosales-Reyes, Tábata</creator><creator>de la Garza, Mireya</creator><creator>Arias-Castro, Carlos</creator><creator>Rodríguez-Mendiola, Martha</creator><creator>Fattel-Fazenda, Samia</creator><creator>Arce-Popoca, Evelia</creator><creator>Hernández-García, Sergio</creator><creator>Villa-Treviño, Saúl</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>20080212</creationdate><title>Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats</title><author>Rosales-Reyes, Tábata ; de la Garza, Mireya ; Arias-Castro, Carlos ; Rodríguez-Mendiola, Martha ; Fattel-Fazenda, Samia ; Arce-Popoca, Evelia ; Hernández-García, Sergio ; Villa-Treviño, Saúl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-4d35cbb7dfca1a1d5b31ed569f998790a0a2ea367e2a4c7b0e6a66b988da69863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>altered hepatocytes foci</topic><topic>animal models</topic><topic>Animals</topic><topic>anticarcinogenic activity</topic><topic>Biological and medical sciences</topic><topic>chemoprevention</topic><topic>Chemopreventive effect</topic><topic>Commelinaceae</topic><topic>Commelinaceae - chemistry</topic><topic>Commelinaceae family</topic><topic>dosage</topic><topic>gamma-Glutamyltransferase - analysis</topic><topic>General pharmacology</topic><topic>Hepatocarcinogenesis</topic><topic>hepatocytes</topic><topic>Hormesis</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>liver neoplasms</topic><topic>Liver Neoplasms, Experimental - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicinal plants</topic><topic>medicinal properties</topic><topic>Medicine, Traditional</topic><topic>Mexico</topic><topic>peptidases</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Precancerous Conditions - chemically induced</topic><topic>Precancerous Conditions - drug therapy</topic><topic>Purple maguey</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rhoeo</topic><topic>Rhoeo discolor</topic><topic>Tradescantia</topic><topic>traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosales-Reyes, Tábata</creatorcontrib><creatorcontrib>de la Garza, Mireya</creatorcontrib><creatorcontrib>Arias-Castro, Carlos</creatorcontrib><creatorcontrib>Rodríguez-Mendiola, Martha</creatorcontrib><creatorcontrib>Fattel-Fazenda, Samia</creatorcontrib><creatorcontrib>Arce-Popoca, Evelia</creatorcontrib><creatorcontrib>Hernández-García, Sergio</creatorcontrib><creatorcontrib>Villa-Treviño, Saúl</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosales-Reyes, Tábata</au><au>de la Garza, Mireya</au><au>Arias-Castro, Carlos</au><au>Rodríguez-Mendiola, Martha</au><au>Fattel-Fazenda, Samia</au><au>Arce-Popoca, Evelia</au><au>Hernández-García, Sergio</au><au>Villa-Treviño, Saúl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-02-12</date><risdate>2008</risdate><volume>115</volume><issue>3</issue><spage>381</spage><epage>386</epage><pages>381-386</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>There are many plants in Mexico with medicinal properties, some of them used in alternative medicine to treat cancer, such is the case of
Rhoeo discolor L. Hér Hance (
Commelinaceae family); however, there are not scientific reports that validate their antitumoral property. The present study shows the protective effects of the
Rhoeo discolor aqueous crude extract (ACE) against rat liver cancer using the resistant-hepatocyte model. The carcinogenesis protocol consisted on the initiation with
N-diethylnitrosamine, followed by the promotion with 2-acetylaminofluorene and a partial hepatectomy. After 24 days, the γ-glutamyl transpeptidase positive, corresponding to altered hepatocytes foci (AHF), were quantified. Additionally to discard a possible carcinogenic effect of ACE, it was first tested as promoting agent instead 2-acetylaminofluorene, and second, ACE was administered as initiator and promoter instead of the whole carcinogenic treatment. In summary, firstly, ACE administration reduced the number and area of preneoplastic lesions with dose below 20
mg/kg body weight and secondly, ACE administration neither presented a promoting or initiator effects nor induced the development of AHF. Results of this investigation justify continuing with further studies of
Rhoeo discolor components to develop chemoprevention strategies as an option in the treatment of cancer.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18063494</pmid><doi>10.1016/j.jep.2007.10.022</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2008-02, Vol.115 (3), p.381-386 |
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| source | ScienceDirect Journals |
| subjects | altered hepatocytes foci animal models Animals anticarcinogenic activity Biological and medical sciences chemoprevention Chemopreventive effect Commelinaceae Commelinaceae - chemistry Commelinaceae family dosage gamma-Glutamyltransferase - analysis General pharmacology Hepatocarcinogenesis hepatocytes Hormesis liver Liver - drug effects Liver - pathology liver neoplasms Liver Neoplasms, Experimental - prevention & control Male Medical sciences Medicinal plants medicinal properties Medicine, Traditional Mexico peptidases Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Precancerous Conditions - chemically induced Precancerous Conditions - drug therapy Purple maguey Rats Rats, Inbred F344 Rhoeo Rhoeo discolor Tradescantia traditional medicine |
| title | Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats |
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