Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo

Epidermal growth factor receptor (EGFR) is an important anti-cancer therapy target that is applicable to many cancer types. We had previously reported the screening and discovery of a novel peptide ligand against EGFR named GE11. It was shown to bind to EGFR competitively with EGF and mediate gene d...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 2008-11, Vol.363 (1), p.155-161
Main Authors: Song, Shuxian, Liu, Dan, Peng, Jinliang, Sun, Ye, Li, Zonghai, Gu, Jian-Ren, Xu, Yuhong
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - metabolism
Biological and medical sciences
Cell Line, Tumor
Cell Survival - drug effects
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Doxorubicin - metabolism
Drug Carriers
Drug Compounding
EGFR
Endocytosis
Feasibility Studies
General pharmacology
Humans
Inhibitory Concentration 50
Injections, Intravenous
Ligands
Lipids - chemistry
Liposome
Liposomes
Lung Neoplasms - drug therapy
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Medical sciences
Mice
Peptide ligand
Peptides - chemistry
Peptides - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Receptor, Epidermal Growth Factor - metabolism
Time Factors
Tumor targeting
Xenograft Model Antitumor Assays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidermal growth factor receptor (EGFR) is an important anti-cancer therapy target that is applicable to many cancer types. We had previously reported the screening and discovery of a novel peptide ligand against EGFR named GE11. It was shown to bind to EGFR competitively with EGF and mediate gene delivery to cancer cells with high-EGFR expression. In this study, we conjugated GE11 on to liposome surface and examined their binding and distribution to EGFR expressing cancer cells in vitro and in vivo using fluorescence imaging techniques. GE11 liposomes were found to bind specifically and efficiently to EGFR high-expressing cancer cells. In vivo in H1299 xenograft mouse model, GE11 liposomes also extravasated and accumulated into the tumor site preferentially, and demonstrated better targeting and drug delivery capacities.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2008.07.012