S100B secretion is stimulated by IL-1β in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway

Abstract S100B is an astrocyte-derived cytokine implicated in the IL-1β-triggered cytokine cycle in Alzheimer's disease. However, the secretion of S100B following stimulation by IL-1β has not been directly demonstrated. We investigated S100B secretion in cortical primary astrocyte cultures, C6...

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Published in:Journal of neuroimmunology 2009-01, Vol.206 (1), p.52-57
Main Authors: de Souza, Daniela F, Leite, Marina C, Quincozes-Santos, André, Nardin, Patrícia, Tortorelli, Lucas S, Rigo, Maurício M, Gottfried, Carmem, Leal, Rodrigo B, Gonçalves, Carlos-Alberto
Format: Article
Language:English
Subjects:
Allergy and Immunology
Astrocyte
Interleukin-1β
MAPK
Neurology
NF-кB
S100B secretion
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Summary:Abstract S100B is an astrocyte-derived cytokine implicated in the IL-1β-triggered cytokine cycle in Alzheimer's disease. However, the secretion of S100B following stimulation by IL-1β has not been directly demonstrated. We investigated S100B secretion in cortical primary astrocyte cultures, C6 glioma cells and acute hippocampal slices exposed to IL-1β. S100B secretion was induced by IL-1β in all preparations, involving MAPK pathway and, apparently, NF-кB signaling. Astrocytes and C6 cells exhibited different sensitivities to IL-1β. These results suggest that IL-1β-induced S100B secretion is a component of the neuroinflammatory response, which would support the involvement of S100B in the genesis of neurodegenerative diseases.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2008.10.012