Fertility preservation in testicular cancer – predictors of spermatogenesis

Objectives To determine the frequency of spermatogenesis in patients with testicular cancer and to assess for any predictors of spermatogenesis. Patients and Methods We retrospectively reviewed 103 testicular germ cell tumours (TGCTs) in men who underwent radical orchidectomy conducted at Guy's...

Full description

Saved in:
Bibliographic Details
Published in:BJU international 2018-08, Vol.122 (2), p.236-242
Main Authors: Moody, Jemma A., Ahmed, Kamran, Horsfield, Catherine, Pedersen, Malene R.V., Yap, Tet, Shabbir, Majid
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biomarkers
Biomarkers, Tumor - metabolism
Calcinosis - pathology
Calcinosis - physiopathology
Cancer
Fertility
fertility preservation
Fertility Preservation - methods
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - physiopathology
Neoplasms, Germ Cell and Embryonal - surgery
onco‐TESE
Orchidectomy
Orchiectomy - methods
Organ Sparing Treatments - methods
Preservation
Retrospective Studies
Sperm
Spermatogenesis
Spermatogenesis - physiology
TCSM
Testes
Testicular cancer
Testicular Neoplasms - pathology
Testicular Neoplasms - physiopathology
Testicular Neoplasms - surgery
TesticularCancer
testis
Testis - physiology
Testis - surgery
Treatment Outcome
Tumor Burden - physiology
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To determine the frequency of spermatogenesis in patients with testicular cancer and to assess for any predictors of spermatogenesis. Patients and Methods We retrospectively reviewed 103 testicular germ cell tumours (TGCTs) in men who underwent radical orchidectomy conducted at Guy's Hospital, London, between 2011 and 2015. Primary outcome measures included: the presence and characteristics of spermatogenesis (widespread/focal/proximity to tumour). Secondary outcome measures included: the presence of testicular microlithiasis, tumour characteristics (size, stage, and type), and tumour markers. Secondary outcome measures as potential predictors of spermatogenesis were assessed using univariate and multivariate logistic regression analyses. Results Spermatogenesis was present in 70% (72/103) of the patients; it was widespread in 63% (45/72) and focal in 38% (27/72). Neither tumour type, stage, presence of microcalcification nor tumour markers predicted spermatogenesis. Men with a percentage testis tumour occupation (PTTO) of >50% of their testis were 82% (95% confidence interval 73.2–98.4) less likely to have spermatogenesis than a PTTO of
ISSN:1464-4096
1464-410X
DOI:10.1111/bju.14214