Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium

Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey’s analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2018-04, Vol.81 (4), p.1103-1107
Main Authors: Sueyoshi, Kosuke, Yamada, Miki, Yamano, Aki, Ozaki, Kaori, Sumimoto, Shimpei, Iwasaki, Arihiro, Suenaga, Kiyotake, Teruya, Toshiaki
Format: Article
Language:English
Subjects:
Animals
Aquatic Organisms - chemistry
Cell Line
Cyanobacteria - chemistry
Drug Screening Assays, Antitumor - methods
Lipopeptides - chemistry
Pyrrolidines - chemistry
Rats
Structure-Activity Relationship
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Summary:Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey’s analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose uptake in cultured rat L6 myotubes. In particular, ypaoamide B (1) showed potent activity and activated AMP-activated protein kinase.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.8b00088