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Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014
Nickel is a common allergen responsible for allergic contact dermatitis. To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years). Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis...
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| Published in: | Journal of the American Academy of Dermatology 2018-10, Vol.79 (4), p.664-671 |
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| cites | cdi_FETCH-LOGICAL-c356t-c6537b30724c3ec719dd08f3dc7ce88b4199393dbd314256abe7ba87049ad1153 |
| container_end_page | 671 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Warshaw, Erin M. Aschenbeck, Kelly A. DeKoven, Joel G. Maibach, Howard I. Taylor, James S. Sasseville, Denis Belsito, Donald V. Fowler, Joseph F. Zug, Kathryn A. Zirwas, Matthew J. Fransway, Anthony F. DeLeo, Vincent A. Marks, James G. Pratt, Melanie D. Mathias, Toby |
| description | Nickel is a common allergen responsible for allergic contact dermatitis.
To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).
Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. We evaluated demographics, rates of reaction to nickel, strength of nickel reactions, and nickel allergy sources.
The frequency of nickel sensitivity was 23.7%. Children with nickel sensitivity were significantly less likely to be male (P |
| doi_str_mv | 10.1016/j.jaad.2018.02.071 |
| format | article |
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To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).
Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. We evaluated demographics, rates of reaction to nickel, strength of nickel reactions, and nickel allergy sources.
The frequency of nickel sensitivity was 23.7%. Children with nickel sensitivity were significantly less likely to be male (P < .0001; relative risk, 0.63; 95% confidence interval, 0.52-0.75) or have a history of allergic rhinitis (P = .0017; relative risk, 0.74; 95% confidence interval, 0.61-0.90) compared with those who were not nickel sensitive. In the nickel-sensitive cohort, the relative proportion of boys declined with age (44.8% for age ≤5, 36.6% for age 6-12, and 22.6% for age 13-18 years). The most common body site distribution for all age groups sensitive to nickel was scattered/generalized, indicating widespread dermatitis. Jewelry was the most common source associated with nickel sensitivity (36.4%).
As a cross-sectional study, no long-term follow-up was available.
Nickel sensitivity in children was common; the frequency was significantly higher in girls than in boys. Overall, sensitivity decreased with age. The most common source of nickel was jewelry.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2018.02.071</identifier><identifier>PMID: 29665973</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Age Distribution ; allergic contact dermatitis ; Child ; Child, Preschool ; children ; Cross-Sectional Studies ; Databases, Factual ; Dermatitis, Allergic Contact - epidemiology ; Dermatitis, Allergic Contact - etiology ; Female ; Humans ; Hypersensitivity - epidemiology ; Hypersensitivity - etiology ; Hypersensitivity - physiopathology ; Incidence ; jewelry ; Male ; nickel ; Nickel - adverse effects ; Nickel - immunology ; North America - epidemiology ; North American Contact Dermatitis Group ; Patch Tests ; pediatric ; Retrospective Studies ; Risk Assessment ; Sex Distribution</subject><ispartof>Journal of the American Academy of Dermatology, 2018-10, Vol.79 (4), p.664-671</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-c6537b30724c3ec719dd08f3dc7ce88b4199393dbd314256abe7ba87049ad1153</citedby><cites>FETCH-LOGICAL-c356t-c6537b30724c3ec719dd08f3dc7ce88b4199393dbd314256abe7ba87049ad1153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29665973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warshaw, Erin M.</creatorcontrib><creatorcontrib>Aschenbeck, Kelly A.</creatorcontrib><creatorcontrib>DeKoven, Joel G.</creatorcontrib><creatorcontrib>Maibach, Howard I.</creatorcontrib><creatorcontrib>Taylor, James S.</creatorcontrib><creatorcontrib>Sasseville, Denis</creatorcontrib><creatorcontrib>Belsito, Donald V.</creatorcontrib><creatorcontrib>Fowler, Joseph F.</creatorcontrib><creatorcontrib>Zug, Kathryn A.</creatorcontrib><creatorcontrib>Zirwas, Matthew J.</creatorcontrib><creatorcontrib>Fransway, Anthony F.</creatorcontrib><creatorcontrib>DeLeo, Vincent A.</creatorcontrib><creatorcontrib>Marks, James G.</creatorcontrib><creatorcontrib>Pratt, Melanie D.</creatorcontrib><creatorcontrib>Mathias, Toby</creatorcontrib><title>Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Nickel is a common allergen responsible for allergic contact dermatitis.
To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).
Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. We evaluated demographics, rates of reaction to nickel, strength of nickel reactions, and nickel allergy sources.
The frequency of nickel sensitivity was 23.7%. Children with nickel sensitivity were significantly less likely to be male (P < .0001; relative risk, 0.63; 95% confidence interval, 0.52-0.75) or have a history of allergic rhinitis (P = .0017; relative risk, 0.74; 95% confidence interval, 0.61-0.90) compared with those who were not nickel sensitive. In the nickel-sensitive cohort, the relative proportion of boys declined with age (44.8% for age ≤5, 36.6% for age 6-12, and 22.6% for age 13-18 years). The most common body site distribution for all age groups sensitive to nickel was scattered/generalized, indicating widespread dermatitis. Jewelry was the most common source associated with nickel sensitivity (36.4%).
As a cross-sectional study, no long-term follow-up was available.
Nickel sensitivity in children was common; the frequency was significantly higher in girls than in boys. Overall, sensitivity decreased with age. The most common source of nickel was jewelry.</description><subject>Adolescent</subject><subject>Age Distribution</subject><subject>allergic contact dermatitis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Cross-Sectional Studies</subject><subject>Databases, Factual</subject><subject>Dermatitis, Allergic Contact - epidemiology</subject><subject>Dermatitis, Allergic Contact - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>Hypersensitivity - etiology</subject><subject>Hypersensitivity - physiopathology</subject><subject>Incidence</subject><subject>jewelry</subject><subject>Male</subject><subject>nickel</subject><subject>Nickel - adverse effects</subject><subject>Nickel - immunology</subject><subject>North America - epidemiology</subject><subject>North American Contact Dermatitis Group</subject><subject>Patch Tests</subject><subject>pediatric</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhq0KRLeFP9BD5WM5JPVHYseIy2pblkpVkRCcLceeBW-TONjeor33h-PVFo6cRhq9z6uZB6ELSmpKqLje1ltjXM0I7WrCaiLpCVpQomQlZCdfoQWhilRKMHaKzlLaEkJUw-UbdMqUEK2SfIGeb2fvYPRhCD_2OGzwDM6bHL3Fk7ePMOAEU_LZP_m8_4C_Qo4hzWDLAnCEJw-_D9RDiPknXo5QQDPhVZiysRnfQBxNLnTC6xh2M756WK5u1u-xM9lgqlRTleubt-j1xgwJ3r3Mc_T90-231efq_sv6brW8ryxvRa6saLnsOZGssRyspMo50m24s9JC1_VNKeSKu95x2rBWmB5kbzpJGmUcpS0_R1fH3jmGXztIWY8-WRgGM0HYJc0Ik0RIKVSJsmPUln9ThI2eox9N3GtK9MG-3uqDfX2wrwnTxX6BLl_6d_0I7h_yV3cJfDwGoHxZ3EWdrIfJFuexONUu-P_1_wFWjpVw</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Warshaw, Erin M.</creator><creator>Aschenbeck, Kelly A.</creator><creator>DeKoven, Joel G.</creator><creator>Maibach, Howard I.</creator><creator>Taylor, James S.</creator><creator>Sasseville, Denis</creator><creator>Belsito, Donald V.</creator><creator>Fowler, Joseph F.</creator><creator>Zug, Kathryn A.</creator><creator>Zirwas, Matthew J.</creator><creator>Fransway, Anthony F.</creator><creator>DeLeo, Vincent A.</creator><creator>Marks, James G.</creator><creator>Pratt, Melanie D.</creator><creator>Mathias, Toby</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014</title><author>Warshaw, Erin M. ; Aschenbeck, Kelly A. ; DeKoven, Joel G. ; Maibach, Howard I. ; Taylor, James S. ; Sasseville, Denis ; Belsito, Donald V. ; Fowler, Joseph F. ; Zug, Kathryn A. ; Zirwas, Matthew J. ; Fransway, Anthony F. ; DeLeo, Vincent A. ; Marks, James G. ; Pratt, Melanie D. ; Mathias, Toby</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-c6537b30724c3ec719dd08f3dc7ce88b4199393dbd314256abe7ba87049ad1153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Age Distribution</topic><topic>allergic contact dermatitis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Cross-Sectional Studies</topic><topic>Databases, Factual</topic><topic>Dermatitis, Allergic Contact - epidemiology</topic><topic>Dermatitis, Allergic Contact - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>Hypersensitivity - etiology</topic><topic>Hypersensitivity - physiopathology</topic><topic>Incidence</topic><topic>jewelry</topic><topic>Male</topic><topic>nickel</topic><topic>Nickel - adverse effects</topic><topic>Nickel - immunology</topic><topic>North America - epidemiology</topic><topic>North American Contact Dermatitis Group</topic><topic>Patch Tests</topic><topic>pediatric</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warshaw, Erin M.</creatorcontrib><creatorcontrib>Aschenbeck, Kelly A.</creatorcontrib><creatorcontrib>DeKoven, Joel G.</creatorcontrib><creatorcontrib>Maibach, Howard I.</creatorcontrib><creatorcontrib>Taylor, James S.</creatorcontrib><creatorcontrib>Sasseville, Denis</creatorcontrib><creatorcontrib>Belsito, Donald V.</creatorcontrib><creatorcontrib>Fowler, Joseph F.</creatorcontrib><creatorcontrib>Zug, Kathryn A.</creatorcontrib><creatorcontrib>Zirwas, Matthew J.</creatorcontrib><creatorcontrib>Fransway, Anthony F.</creatorcontrib><creatorcontrib>DeLeo, Vincent A.</creatorcontrib><creatorcontrib>Marks, James G.</creatorcontrib><creatorcontrib>Pratt, Melanie D.</creatorcontrib><creatorcontrib>Mathias, Toby</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warshaw, Erin M.</au><au>Aschenbeck, Kelly A.</au><au>DeKoven, Joel G.</au><au>Maibach, Howard I.</au><au>Taylor, James S.</au><au>Sasseville, Denis</au><au>Belsito, Donald V.</au><au>Fowler, Joseph F.</au><au>Zug, Kathryn A.</au><au>Zirwas, Matthew J.</au><au>Fransway, Anthony F.</au><au>DeLeo, Vincent A.</au><au>Marks, James G.</au><au>Pratt, Melanie D.</au><au>Mathias, Toby</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>79</volume><issue>4</issue><spage>664</spage><epage>671</epage><pages>664-671</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Nickel is a common allergen responsible for allergic contact dermatitis.
To characterize nickel sensitivity in children and compare pediatric cohorts (≤5, 6-12, and 13-18 years).
Retrospective, cross-sectional analysis of 1894 pediatric patients patch tested by the North American Contact Dermatitis Group from 1994 to 2014. We evaluated demographics, rates of reaction to nickel, strength of nickel reactions, and nickel allergy sources.
The frequency of nickel sensitivity was 23.7%. Children with nickel sensitivity were significantly less likely to be male (P < .0001; relative risk, 0.63; 95% confidence interval, 0.52-0.75) or have a history of allergic rhinitis (P = .0017; relative risk, 0.74; 95% confidence interval, 0.61-0.90) compared with those who were not nickel sensitive. In the nickel-sensitive cohort, the relative proportion of boys declined with age (44.8% for age ≤5, 36.6% for age 6-12, and 22.6% for age 13-18 years). The most common body site distribution for all age groups sensitive to nickel was scattered/generalized, indicating widespread dermatitis. Jewelry was the most common source associated with nickel sensitivity (36.4%).
As a cross-sectional study, no long-term follow-up was available.
Nickel sensitivity in children was common; the frequency was significantly higher in girls than in boys. Overall, sensitivity decreased with age. The most common source of nickel was jewelry.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29665973</pmid><doi>10.1016/j.jaad.2018.02.071</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 2018-10, Vol.79 (4), p.664-671 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | Elsevier |
| subjects | Adolescent Age Distribution allergic contact dermatitis Child Child, Preschool children Cross-Sectional Studies Databases, Factual Dermatitis, Allergic Contact - epidemiology Dermatitis, Allergic Contact - etiology Female Humans Hypersensitivity - epidemiology Hypersensitivity - etiology Hypersensitivity - physiopathology Incidence jewelry Male nickel Nickel - adverse effects Nickel - immunology North America - epidemiology North American Contact Dermatitis Group Patch Tests pediatric Retrospective Studies Risk Assessment Sex Distribution |
| title | Epidemiology of pediatric nickel sensitivity: Retrospective review of North American Contact Dermatitis Group (NACDG) data 1994-2014 |
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