Inhibiting EBV: The Key to Carefree Smooching

There are no vaccines or therapies to treat Epstein-Barr virus (EBV). Snijder et al. (2018) isolated a potent human antibody against EBV that blocks infection of both B cells and epithelial cells. Structural analysis of the antibody complexed with a viral surface protein complex identified a site th...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2018-04, Vol.48 (4), p.623-625
Main Author: Lok, Shee-Mei
Format: Article
Language:English
Subjects:
Crystallography
Epithelial cells
Epstein-Barr virus
Immunoglobulins
Infections
Lymphocytes B
Mutagenesis
Proteins
Structural analysis
Vaccine development
Vaccines
Viral infections
Viruses
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Summary:There are no vaccines or therapies to treat Epstein-Barr virus (EBV). Snijder et al. (2018) isolated a potent human antibody against EBV that blocks infection of both B cells and epithelial cells. Structural analysis of the antibody complexed with a viral surface protein complex identified a site that may be useful in vaccine development. There are no vaccines or therapies to treat Epstein-Barr virus (EBV). Snijder et al. (2018) isolated a potent human antibody against EBV that blocks infection of both B cells and epithelial cells. Structural analysis of the antibody complexed with a viral surface protein complex identified a site that may be useful in vaccine development.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2018.03.036