Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy

Delayed post-hypoxic encephalopathy is an uncommon but potentially debilitating consequence of hypoxic-ischemic brain injury. This condition is characterized by delayed neurological deterioration days-to-weeks after an initial partial or complete recovery from hypoxic-ischemic brain injury. The cour...

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Bibliographic Details
Published in:Brain injury 2004-12, Vol.18 (12), p.1309-1318
Main Authors: Arciniegas, David B., Frey, Kimberly L., Alan Anderson, C., Brousseau, Kristin M., Harris, Susie N.
Format: Article
Language:English
Subjects:
Adult
Amantadine - therapeutic use
Brain - pathology
Brain Injuries - complications
Cognition Disorders - drug therapy
Cognition Disorders - etiology
Demyelinating Diseases - drug therapy
Demyelinating Diseases - etiology
Diazepam - poisoning
Dopamine Agents - therapeutic use
Humans
Hypnotics and Sedatives - poisoning
Hypoxia-Ischemia, Brain - complications
Magnetic Resonance Imaging - methods
Male
Mental Disorders - drug therapy
Mental Disorders - etiology
Methadone - poisoning
Narcotics - poisoning
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Summary:Delayed post-hypoxic encephalopathy is an uncommon but potentially debilitating consequence of hypoxic-ischemic brain injury. This condition is characterized by delayed neurological deterioration days-to-weeks after an initial partial or complete recovery from hypoxic-ischemic brain injury. The course of recovery from this condition is highly variable, ranging from rapid and fatal progression over several weeks to delayed but occasionally complete recovery. There are no reports describing neurorehabilitative, including neuropharmacologic, interventions for persons with persistent neurological and or neurobehavioural deficits following delayed post-hypoxic encephalopathy. This study describes the case of a 24-year old male who developed delayed post-hypoxic encephalopathy following an unintentional methadone and diazepam overdose and who demonstrated cognitive and neurobehavioural improvements during treatment with amantadine HCl hydrochloride in a single-case, open-label design. A brief review of the literature regarding this condition, its treatment and suggestions for further study are presented.
ISSN:0269-9052
1362-301X
DOI:10.1080/02699050410001720130