Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat

Recent studies have demonstrated that neuropeptide Y (NPY) reduced the neural production of dehydroepiandrosterone (DHEA) in frog hypothalamic explants. The objective of this study was to assess if DHEA can block the NPY induced increase in food intake in lean and obese Zucker rats. Rats were given...

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Bibliographic Details
Published in:Nutritional neuroscience 2006-10, Vol.9 (5-6), p.225-232
Main Authors: Navar, Daniel, S'Aulis, Dana, Corll, Connie, Svec, Frank, Porter, Johnny R.
Format: Article
Language:English
Subjects:
Animal Feed
Animals
Anura
DEHYDROEPIANDROSTERONE
Dehydroepiandrosterone - pharmacology
Dose-Response Relationship, Drug
Energy Intake - drug effects
Female
FOOD INTAKE
NEUROPEPTIDE Y
Neuropeptide Y - physiology
Obesity - genetics
Obesity - physiopathology
Rats
Rats, Zucker
SEROTONIN
VENTROMEDIAL HYPOTHALAMUS
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Summary:Recent studies have demonstrated that neuropeptide Y (NPY) reduced the neural production of dehydroepiandrosterone (DHEA) in frog hypothalamic explants. The objective of this study was to assess if DHEA can block the NPY induced increase in food intake in lean and obese Zucker rats. Rats were given one of the following four treatments: sterile water/dimethylsulfoxide (DMSO), NPY/DMSO, water/DHEA, and NPY/DHEA. Immediately after administration of their respective treatment, rats were exposed to macronutrients for 4 h and food intake was monitored. NPY caused a significant increase in total calories consumed compared to control. Co-administration of DHEA along with NPY blocked this NPY dependent effect. These results suggest that DHEA blocks the over-eating in satiated rats induced by NPY. Measurement of changes in regional hypothalamic and raphe monoamine neurotransmitters known to affect food intake suggested a possible role of serotonin fluctuations in the ventromedial hypothalamus (VMH) guiding this behaviour.
ISSN:1028-415X
1476-8305
DOI:10.1080/10284150601090102