Phytotherapeutics in cancer invasion and metastasis

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angi...

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Bibliographic Details
Published in:Phytotherapy research 2018-08, Vol.32 (8), p.1425-1449
Main Authors: Salehi, Bahare, Zucca, Paolo, Sharifi‐Rad, Mehdi, Pezzani, Raffaele, Rajabi, Sadegh, Setzer, William N., Varoni, Elena Maria, Iriti, Marcello, Kobarfard, Farzad, Sharifi‐Rad, Javad
Format: Article
Language:English
Subjects:
adjuvant therapy
Adjuvants
Angiogenesis
Animals
Antiangiogenics
anticancer drugs
Anticancer properties
Antineoplastic Agents, Phytogenic - pharmacology
Antitumor agents
Cancer
cancer chemoprevention
Carcinogenesis
Carcinogens
chemotherapy
Drug discovery
Humans
Metastases
Metastasis
Neoplasms - drug therapy
phytochemicals
Phytochemicals - pharmacology
Phytotherapy
plant products
Plants - chemistry
Signal Transduction - drug effects
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Summary:Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6087