Antibacterial Indole Alkaloids with Complex Heterocycles from Voacanga africana

Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a...

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Bibliographic Details
Published in:Organic letters 2018-05, Vol.20 (9), p.2702-2706
Main Authors: Ding, Cai-Feng, Ma, Hong-Xia, Yang, Jing, Qin, Xu-Jie, Njateng, Guy S. S, Yu, Hao-Fei, Wei, Xin, Liu, Ya-Ping, Huang, Wan-Yi, Yang, Zi-Feng, Wang, Xin-Hua, Luo, Xiao-Dong
Format: Article
Language:English
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Summary:Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19-epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00913