A unifying concept in vascular health and disease

Interventions to restore blood vessel stability could improve health outcomes Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly differ...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2018-04, Vol.360 (6386), p.270-271
Main Authors: Schwartz, Martin A, Vestweber, Dietmar, Simons, Michael
Format: Article
Language:English
Subjects:
Blood vessels
Blood Vessels - abnormalities
Blood Vessels - pathology
Blood Vessels - physiopathology
Commonality
Humans
Neovascularization, Physiologic
Vascular diseases
Vascular Diseases - physiopathology
Vascular Remodeling
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Summary:Interventions to restore blood vessel stability could improve health outcomes Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. But is this really the case? An evaluation of the literature suggests that unresolved vascular remodeling may be a key element of virtually all vascular diseases. This commonality raises the possibility of unifying principles that govern vascular remodeling and the possibility that methods to restore normal remodeling could effectively treat multiple disease states.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aat3470