Intra-uterine growth retardation after prenatal administration of Ginkgo biloba to rats

Ginkgo biloba is a plant used in the treatment of Alzheimer's disease, cerebrovascular insufficiency and peripheral vascular diseases that showed reproductive toxicity in vitro and in the mouse model. In this study, pregnant Wistar rats received 0, 3.5, 7 and 14 mg/kg body weight/day of G. bilo...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2007-06, Vol.23 (4), p.480-485
Main Authors: Pinto, Rafael M., Fernandes, Eduardo S., Reis, João E.P., Peters, Vera M., Guerra, Martha de O.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Developmental toxicity
Diseases of mother, fetus and pregnancy
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Growth Retardation - chemically induced
Fetal Growth Retardation - physiopathology
Fetal Weight - drug effects
Fetogenesis
Fundamental and applied biological sciences. Psychology
Gestational Age
Ginkgo biloba
Growth retardation
Gynecology. Andrology. Obstetrics
Liver - drug effects
Liver - embryology
Male
Medical sciences
Organogenesis
Plant Extracts - toxicity
Pregnancy
Pregnancy. Fetus. Placenta
Rats
Rats, Wistar
Teratology. Teratogens
Toxicology
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Summary:Ginkgo biloba is a plant used in the treatment of Alzheimer's disease, cerebrovascular insufficiency and peripheral vascular diseases that showed reproductive toxicity in vitro and in the mouse model. In this study, pregnant Wistar rats received 0, 3.5, 7 and 14 mg/kg body weight/day of G. biloba, by gavage, from the 8th to 20th day of pregnancy. Rats were killed on the 21st day and the following parameters were evaluated: maternal body weight; food and water intake; maternal's liver, kidney and ovary weights; resorption index; post-implantation loss; mean of live fetuses; fetuses and placenta mean weight; fetuses’ liver, kidney, lung and brain weights; fetuses’ external malformations. No significant alteration was observed in maternal parameters of toxicity, but the treatment with 7 and 14 mg/kg/day of G. biloba caused significant decrease in the fetuses mean weights. The results indicated that G. biloba was not toxic to mothers, although it caused fetal intra-uterine growth retardation.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2006.12.008