Tumour-associated macrophages: Relation with progression and invasiveness, and assessment of M1/M2 macrophages in canine mammary tumours

•Tumour-associated macrophage (TAM) counts are higher in more aggressive histotypes of canine mammary tumors (CMTs).•TAM counts are related to various clinicopathological parameters and overall survival in CMTs.•Macrophages subpopulations are predominantly of M1 type in benign CMTs and of M2 type in...

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Bibliographic Details
Published in:The veterinary journal (1997) 2018-04, Vol.234, p.119-125
Main Authors: Monteiro, L.N., Rodrigues, M.A., Gomes, D.A., Salgado, B.S., Cassali, G.D.
Format: Article
Language:English
Subjects:
Canine
Inflammation
Mammary tumour
Tumour microenvironment
Tumour-associated macrophages
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Summary:•Tumour-associated macrophage (TAM) counts are higher in more aggressive histotypes of canine mammary tumors (CMTs).•TAM counts are related to various clinicopathological parameters and overall survival in CMTs.•Macrophages subpopulations are predominantly of M1 type in benign CMTs and of M2 type in malignant CMTs. Macrophages represent a major component of the overall leucocyte population within neoplasms and are important for tumour behaviour in several cancers in human beings. However, little information regarding their role in canine mammary tumours (CMTs) is available. The aim of this study was to address the potential role of tumour-associated macrophages (TAMs) in CMTs. TAMs in CMTs excised from 82 female dogs were quantified at high power (400× magnification) and categorised as low (≤50) or high (>50) TAM counts. Higher TAM counts were associated with clinical stage (P
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2018.02.016