A Novel Regulator of Type II Diabetes: MicroRNA-143

MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM)...

Full description

Saved in:
Bibliographic Details
Published in:Trends in endocrinology and metabolism 2018-06, Vol.29 (6), p.380-388
Main Authors: Li, Biao, Fan, Jingjing, Chen, Ning
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - therapy
exercise intervention
Exercise Therapy
Humans
insulin resistance
Insulin Resistance - genetics
Insulin Resistance - physiology
MicroRNAs - genetics
MicroRNAs - metabolism
miR-143
ORP8
Receptors, Steroid - genetics
Receptors, Steroid - metabolism
T2DM
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143. Insulin resistance and deficient autophagy are the characteristics of T2DM. MiR-143 can specifically impair the insulin-AKT pathway, which can result in insulin tolerance and progression to T2DM. Insulin resistance can be rescued via activated autophagy through inhibition of miR-143. Aerobic exercise can inhibit miR-143 and activate autophagy, thus mitigating or rescuing insulin resistance in metabolic dieseases.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2018.03.019