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Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia
Objective Masticatory muscle tendon‐aponeurosis hyperplasia, which is associated with limited mouth opening, progresses very slowly from adolescence. The prevalence rates of this disease are higher among women than among men, suggesting oestrogen involvement. As parafunctional habits are frequently...
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| Published in: | Oral diseases 2019-01, Vol.25 (1), p.274-281 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c3886-c86d46c354770909386417491fb53e311fde1697d4fe7d5894c2692f4aa069a43 |
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| cites | cdi_FETCH-LOGICAL-c3886-c86d46c354770909386417491fb53e311fde1697d4fe7d5894c2692f4aa069a43 |
| container_end_page | 281 |
| container_issue | 1 |
| container_start_page | 274 |
| container_title | Oral diseases |
| container_volume | 25 |
| creator | Hayashi, N Sato, T Kokabu, S Usui, M Yumoto, M Ikami, E Sakamoto, Y Nifuji, A Hayata, T Noda, M Yoda, T |
| description | Objective
Masticatory muscle tendon‐aponeurosis hyperplasia, which is associated with limited mouth opening, progresses very slowly from adolescence. The prevalence rates of this disease are higher among women than among men, suggesting oestrogen involvement. As parafunctional habits are frequently observed, mechanical stress is likely involved in the pathogenesis and advancement of this disease. To elucidate the pathological condition, we examined the effect of oestrogen on tenocyte function and the relationship between mechanical stress and crystallin beta A4 (Cryba4), using murine TT‐D6 tenocytes.
Materials and Methods
Cell proliferation assays, RT‐PCR, real‐time RT‐PCR, Western blot analysis and mechanical loading experiments were performed.
Results
The physiological dose of oestrogen increased the levels of scleraxis and tenomodulin in TT‐D6 tenocytes. In contrast, forced expression of Cryba4 inhibited scleraxis expression in these cells. Surprisingly, oestrogen significantly promoted cell differentiation in the Cryba4‐overexpressing TT‐D6 tenocytes. Moreover, tensile force induced Cryba4 expression in these tendon cells.
Conclusion
Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon‐aponeurosis hyperplasia. |
| doi_str_mv | 10.1111/odi.12876 |
| format | article |
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Masticatory muscle tendon‐aponeurosis hyperplasia, which is associated with limited mouth opening, progresses very slowly from adolescence. The prevalence rates of this disease are higher among women than among men, suggesting oestrogen involvement. As parafunctional habits are frequently observed, mechanical stress is likely involved in the pathogenesis and advancement of this disease. To elucidate the pathological condition, we examined the effect of oestrogen on tenocyte function and the relationship between mechanical stress and crystallin beta A4 (Cryba4), using murine TT‐D6 tenocytes.
Materials and Methods
Cell proliferation assays, RT‐PCR, real‐time RT‐PCR, Western blot analysis and mechanical loading experiments were performed.
Results
The physiological dose of oestrogen increased the levels of scleraxis and tenomodulin in TT‐D6 tenocytes. In contrast, forced expression of Cryba4 inhibited scleraxis expression in these cells. Surprisingly, oestrogen significantly promoted cell differentiation in the Cryba4‐overexpressing TT‐D6 tenocytes. Moreover, tensile force induced Cryba4 expression in these tendon cells.
Conclusion
Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon‐aponeurosis hyperplasia.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12876</identifier><identifier>PMID: 29683234</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adolescents ; Animals ; Aponeurosis - pathology ; beta-Crystallin A Chain - genetics ; Cell proliferation ; Cells, Cultured ; Cryba4 ; Crystallin ; Dentistry ; differentiation ; Estrogens ; Estrogens - physiology ; Humans ; Hyperplasia ; Mastication ; masticatory muscle tendon‐aponeurosis hyperplasia ; Masticatory Muscles - pathology ; Mechanical loading ; Mice ; oestrogen ; Stress, Mechanical ; Tendons - pathology ; tenocyte ; tensile force</subject><ispartof>Oral diseases, 2019-01, Vol.25 (1), p.274-281</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.</rights><rights>Copyright © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-c86d46c354770909386417491fb53e311fde1697d4fe7d5894c2692f4aa069a43</citedby><cites>FETCH-LOGICAL-c3886-c86d46c354770909386417491fb53e311fde1697d4fe7d5894c2692f4aa069a43</cites><orcidid>0000-0002-1109-196X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29683234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, N</creatorcontrib><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Kokabu, S</creatorcontrib><creatorcontrib>Usui, M</creatorcontrib><creatorcontrib>Yumoto, M</creatorcontrib><creatorcontrib>Ikami, E</creatorcontrib><creatorcontrib>Sakamoto, Y</creatorcontrib><creatorcontrib>Nifuji, A</creatorcontrib><creatorcontrib>Hayata, T</creatorcontrib><creatorcontrib>Noda, M</creatorcontrib><creatorcontrib>Yoda, T</creatorcontrib><title>Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
Masticatory muscle tendon‐aponeurosis hyperplasia, which is associated with limited mouth opening, progresses very slowly from adolescence. The prevalence rates of this disease are higher among women than among men, suggesting oestrogen involvement. As parafunctional habits are frequently observed, mechanical stress is likely involved in the pathogenesis and advancement of this disease. To elucidate the pathological condition, we examined the effect of oestrogen on tenocyte function and the relationship between mechanical stress and crystallin beta A4 (Cryba4), using murine TT‐D6 tenocytes.
Materials and Methods
Cell proliferation assays, RT‐PCR, real‐time RT‐PCR, Western blot analysis and mechanical loading experiments were performed.
Results
The physiological dose of oestrogen increased the levels of scleraxis and tenomodulin in TT‐D6 tenocytes. In contrast, forced expression of Cryba4 inhibited scleraxis expression in these cells. Surprisingly, oestrogen significantly promoted cell differentiation in the Cryba4‐overexpressing TT‐D6 tenocytes. Moreover, tensile force induced Cryba4 expression in these tendon cells.
Conclusion
Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon‐aponeurosis hyperplasia.</description><subject>Adolescents</subject><subject>Animals</subject><subject>Aponeurosis - pathology</subject><subject>beta-Crystallin A Chain - genetics</subject><subject>Cell proliferation</subject><subject>Cells, Cultured</subject><subject>Cryba4</subject><subject>Crystallin</subject><subject>Dentistry</subject><subject>differentiation</subject><subject>Estrogens</subject><subject>Estrogens - physiology</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Mastication</subject><subject>masticatory muscle tendon‐aponeurosis hyperplasia</subject><subject>Masticatory Muscles - pathology</subject><subject>Mechanical loading</subject><subject>Mice</subject><subject>oestrogen</subject><subject>Stress, Mechanical</subject><subject>Tendons - pathology</subject><subject>tenocyte</subject><subject>tensile force</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KxDAUhYMoOv4sfAEJuNFFx_w1TZYy_sLAuFBwFzJpqpG2qUmLdOcj-Iw-idFRF4J3c-_iu4dzDgD7GE1xmhNfuikmouBrYII5whkSJF9PN81ZlhN6vwW2Y3xCCBeSkk2wRSQXlFA2AfbGx-iWtYU6Rm-c7p1voa-gt7EP_sG2ULclnIVxqRl8cf0jbHTsndG9DyNshmjSb2_b0rfvr2-6860dgo8uwsexs6GrdXR6F2xUuo5273vvgLuL89vZVTZfXF7PTueZoULwzAheMm6S66JAEkkqOMMFk7ha5tRSjKvSYi6LklW2KHMhmSFckoppjbjUjO6Ao5VuF_zzkBKoxkVj61q31g9REZSS00ISkdDDP-iTH0Kb3CmCc0YIk1wm6nhFmZQpBlupLrhGh1FhpD67V6l79dV9Yg--FYdlY8tf8qfsBJysgBdX2_F_JbU4u15JfgAOSI7P</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Hayashi, N</creator><creator>Sato, T</creator><creator>Kokabu, S</creator><creator>Usui, M</creator><creator>Yumoto, M</creator><creator>Ikami, E</creator><creator>Sakamoto, Y</creator><creator>Nifuji, A</creator><creator>Hayata, T</creator><creator>Noda, M</creator><creator>Yoda, T</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1109-196X</orcidid></search><sort><creationdate>201901</creationdate><title>Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia</title><author>Hayashi, N ; Sato, T ; Kokabu, S ; Usui, M ; Yumoto, M ; Ikami, E ; Sakamoto, Y ; Nifuji, A ; Hayata, T ; Noda, M ; Yoda, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-c86d46c354770909386417491fb53e311fde1697d4fe7d5894c2692f4aa069a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescents</topic><topic>Animals</topic><topic>Aponeurosis - pathology</topic><topic>beta-Crystallin A Chain - genetics</topic><topic>Cell proliferation</topic><topic>Cells, Cultured</topic><topic>Cryba4</topic><topic>Crystallin</topic><topic>Dentistry</topic><topic>differentiation</topic><topic>Estrogens</topic><topic>Estrogens - physiology</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Mastication</topic><topic>masticatory muscle tendon‐aponeurosis hyperplasia</topic><topic>Masticatory Muscles - pathology</topic><topic>Mechanical loading</topic><topic>Mice</topic><topic>oestrogen</topic><topic>Stress, Mechanical</topic><topic>Tendons - pathology</topic><topic>tenocyte</topic><topic>tensile force</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, N</creatorcontrib><creatorcontrib>Sato, T</creatorcontrib><creatorcontrib>Kokabu, S</creatorcontrib><creatorcontrib>Usui, M</creatorcontrib><creatorcontrib>Yumoto, M</creatorcontrib><creatorcontrib>Ikami, E</creatorcontrib><creatorcontrib>Sakamoto, Y</creatorcontrib><creatorcontrib>Nifuji, A</creatorcontrib><creatorcontrib>Hayata, T</creatorcontrib><creatorcontrib>Noda, M</creatorcontrib><creatorcontrib>Yoda, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, N</au><au>Sato, T</au><au>Kokabu, S</au><au>Usui, M</au><au>Yumoto, M</au><au>Ikami, E</au><au>Sakamoto, Y</au><au>Nifuji, A</au><au>Hayata, T</au><au>Noda, M</au><au>Yoda, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2019-01</date><risdate>2019</risdate><volume>25</volume><issue>1</issue><spage>274</spage><epage>281</epage><pages>274-281</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
Masticatory muscle tendon‐aponeurosis hyperplasia, which is associated with limited mouth opening, progresses very slowly from adolescence. The prevalence rates of this disease are higher among women than among men, suggesting oestrogen involvement. As parafunctional habits are frequently observed, mechanical stress is likely involved in the pathogenesis and advancement of this disease. To elucidate the pathological condition, we examined the effect of oestrogen on tenocyte function and the relationship between mechanical stress and crystallin beta A4 (Cryba4), using murine TT‐D6 tenocytes.
Materials and Methods
Cell proliferation assays, RT‐PCR, real‐time RT‐PCR, Western blot analysis and mechanical loading experiments were performed.
Results
The physiological dose of oestrogen increased the levels of scleraxis and tenomodulin in TT‐D6 tenocytes. In contrast, forced expression of Cryba4 inhibited scleraxis expression in these cells. Surprisingly, oestrogen significantly promoted cell differentiation in the Cryba4‐overexpressing TT‐D6 tenocytes. Moreover, tensile force induced Cryba4 expression in these tendon cells.
Conclusion
Oestrogen and Cryba4 may be associated with the progression of masticatory muscle tendon‐aponeurosis hyperplasia.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29683234</pmid><doi>10.1111/odi.12876</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1109-196X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral diseases, 2019-01, Vol.25 (1), p.274-281 |
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| source | Wiley |
| subjects | Adolescents Animals Aponeurosis - pathology beta-Crystallin A Chain - genetics Cell proliferation Cells, Cultured Cryba4 Crystallin Dentistry differentiation Estrogens Estrogens - physiology Humans Hyperplasia Mastication masticatory muscle tendon‐aponeurosis hyperplasia Masticatory Muscles - pathology Mechanical loading Mice oestrogen Stress, Mechanical Tendons - pathology tenocyte tensile force |
| title | Possible association of oestrogen and Cryba4 with masticatory muscle tendon‐aponeurosis hyperplasia |
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