Odontogenic myxoma: An updated analysis of 1,692 cases reported in the literature

The aim of the present study was to integrate the available data published on odontogenic myxoma (OM) into a comprehensive analysis of its clinical/radiological features. Electronic search undertaken in January/2018, looking for publications reporting cases of OM. A total of 377 publications were in...

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Bibliographic Details
Published in:Oral diseases 2019-04, Vol.25 (3), p.676-683
Main Authors: Chrcanovic, Bruno R., Gomez, Ricardo S.
Format: Article
Language:English
Subjects:
clinical features
Cortical bone
Curettage
Enucleation
fibromyxoma
Mandible
Maxilla
Morbidity
myxofibroma
Myxoma
odontogenic myxoma
odontogenic tumors
Osteotomy
recurrence rate
Root resorption
Septum
Teeth
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Summary:The aim of the present study was to integrate the available data published on odontogenic myxoma (OM) into a comprehensive analysis of its clinical/radiological features. Electronic search undertaken in January/2018, looking for publications reporting cases of OM. A total of 377 publications were included. We identified 1,692 lesions, and 695 were used for the analysis of recurrence. There is a predominance of OMs in females and in mandibles. OMs usually present with bone expansion, asymptomatic cortical perforation, and a multilocular appearance. Lesion location (maxilla/mandible), bone expansion, cortical bone perforation, locular radiological appearance, tooth resorption, odontogenic epithelial rests, or angular septa are not associated with recurrence. While curettage (31.3%) showed the highest recurrence rate, marginal resection (1.3%) and segmental resection (3.1%) showed the lowest values. Enucleation + peripheral osteotomy (6.7%) showed better results than enucleation (13.1%) or enucleation + curettage (12.7%). In comparison with unilocular lesions, multilocular ones were significantly more prevalent in mandibles, more often presented expansion and cortical bone perforation, had larger mean size, and were more often treated by segmental resection. Conservative surgical procedures are associated with higher probability of recurrence of OM. Taking into consideration the recurrence rate and morbidity associated with different surgical treatments, tumor enucleation followed by peripheral osteotomy should be considered as the first therapeutic choice.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12875