Nickel-Catalyzed Deoxycyanation of Activated Phenols via Cyanurate Intermediates with Zn(CN)2: A Route to Aryl Nitriles

A novel, and efficient nickel-catalyzed deoxycyanation of phenolic compounds using relatively nontoxic Zn­(CN)2 as the cyanide source was developed. The reaction of C–O bond activated phenolic compounds by 2,4,6-trichloro-1,3,5-triazine with Zn­(CN)2 in the presence of a nickel precatalyst afforded...

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Bibliographic Details
Published in:Organic letters 2018-05, Vol.20 (9), p.2753-2756
Main Authors: Heravi, Majid M, Panahi, Farhad, Iranpoor, Nasser
Format: Article
Language:English
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Summary:A novel, and efficient nickel-catalyzed deoxycyanation of phenolic compounds using relatively nontoxic Zn­(CN)2 as the cyanide source was developed. The reaction of C–O bond activated phenolic compounds by 2,4,6-trichloro-1,3,5-triazine with Zn­(CN)2 in the presence of a nickel precatalyst afforded the aromatic nitriles in good to excellent yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00974