Influence of maternal nicotine exposure on neonatal rat oxidant–antioxidant system and effect of ascorbic acid supplementation

There have been a few studies that examined the oxidative stress effects of nicotine during pregnancy and lactation. We aimed to determine the adverse effects of maternal nicotine exposure during pregnancy and lactation on oxidant–antioxidant system, and to determine a protective effect of ascorbic...

Full description

Saved in:
Bibliographic Details
Published in:Human & experimental toxicology 2008-10, Vol.27 (10), p.781-786
Main Authors: Gunes, T, Koklu, E, Gunes, I, Narin, F, Koklu, SS
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Antioxidants
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Biological and medical sciences
Birth Weight - drug effects
Female
Fetal Development - drug effects
Injections, Subcutaneous
Lactation - drug effects
Male
Malondialdehyde - blood
Maternal Exposure
Medical sciences
Nicotine
Nicotine - toxicity
Oxidation
Oxidative Stress - drug effects
Oxidoreductases - metabolism
Pregnancy
Prenatal development
Prenatal Exposure Delayed Effects - chemically induced
Rats
Rodents
Tobacco, tobacco smoking
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There have been a few studies that examined the oxidative stress effects of nicotine during pregnancy and lactation. We aimed to determine the adverse effects of maternal nicotine exposure during pregnancy and lactation on oxidant–antioxidant system, and to determine a protective effect of ascorbic acid (Asc). Gravid rats were assigned into four groups. In Group 1, pregnant rats received 6-mg/kg/day nicotine subcutaneously during pregnancy from 1 to 21 days of gestation and lactation (until postnatal day 21). Group 2 received nicotine and Asc for the same period. In Group 3, the rats received nicotine during lactation. Control pregnant rats (Group 4) received only saline subcutaneously. Serum malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD) levels were determined at 21 days of age. Nicotine exposure decreased birth weight and pregnancy weight gain. MDA values of the rat pups exposed to nicotine in both Groups 1 and 2 were higher than those of control and Group 3. SOD and MPO values of the groups were similar. Mean birth weight and serum MDA levels of Groups 1 and 2 were similar. Nicotine exposure via placental transfer increases oxidative stress as manifested by an increase in MDA level. Asc supplementation does not prevent the adverse effects of maternal nicotine exposure.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327107082229