2D:4D and spatial abilities: From rats to humans

•4th but not 2nd digit length is influenced by sex hormones in utero.•2D:4D finger ratio correlates with spatial memory performance in rats and humans.•In humans right caudate nucleus and insula correlate with 2D:4D ratio.•Connectivity of these areas with the prefrontal cortex predicts memory perfor...

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Bibliographic Details
Published in:Neurobiology of learning and memory 2018-05, Vol.151, p.85-87
Main Authors: Müller, N., Campbell, S., Nonaka, M., Rost, T.M., Pipa, G., Konrad, B.N., Steiger, A., Czisch, M., Fernández, G., Dresler, M., Genzel, L.
Format: Article
Language:English
Subjects:
2D:4D
Human
Memory
Prenatal programming
Rat
Spatial abilities
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Summary:•4th but not 2nd digit length is influenced by sex hormones in utero.•2D:4D finger ratio correlates with spatial memory performance in rats and humans.•In humans right caudate nucleus and insula correlate with 2D:4D ratio.•Connectivity of these areas with the prefrontal cortex predicts memory performance. Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and watermaze) and replicated this in humans. We further clarified anatomical and functional brain correlates of the association between 2D:4D and spatial performance in humans.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2018.04.012