Caffeine intake reduces incident atrial fibrillation at a population level

Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of...

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Bibliographic Details
Published in:European journal of preventive cardiology 2018-07, Vol.25 (10), p.1055-1062
Main Authors: Casiglia, Edoardo, Tikhonoff, Valérie, Albertini, Federica, Gasparotti, Federica, Mazza, Alberto, Montagnana, Martina, Danese, Elisa, Benati, Marco, Spinella, Paolo, Palatini, Paolo
Format: Article
Language:English
Subjects:
Age Factors
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - physiopathology
Atrial Fibrillation - prevention & control
Caffeine - administration & dosage
Caffeine - metabolism
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - metabolism
Comorbidity
Cytochrome P-450 CYP1A2 - genetics
Cytochrome P-450 CYP1A2 - metabolism
Female
Genotype
Humans
Incidence
Italy - epidemiology
Male
Middle Aged
Pharmacogenomic Variants
Polymorphism, Genetic
Prospective Studies
Protective Factors
Risk Factors
Time Factors
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Summary:Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected men and women observed for 12 years and left free to intake food or beverages containing caffeine was studied. Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the –163C > A polymorphism of the CYP1A2 gene, regulating caffeine metabolism. Results In the whole cohort, the 12-year incidence of atrial fibrillation was significantly lower in the third (2.2%) than in the first (10.2%) or second (5.7%) tertile of caffeine intake (P  320 mg/day) is associated with a lower incidence of atrial fibrillation in the 12-year epidemiological prospective setting based on the general population.
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487318772945