2-Methyl-versiquinazoline C, a new fumiquinazoline-type alkaloid from the fungus Aspergillus flavipes PJ03-11

A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1), together with six known compounds (2-7), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compou...

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Bibliographic Details
Published in:Journal of asian natural products research 2019-06, Vol.21 (6), p.528-534
Main Authors: Si, Ying-Ying, Tang, Ming-Xu, Lin, Shuang, Chen, Gang, Hua, Hui-Ming, Bai, Jiao, Wang, Yu-Bo, Wang, Hai-Feng, Pei, Yue-Hu
Format: Article
Language:English
Subjects:
Absolute configuration
Alkaloids - chemistry
Alkaloids - pharmacology
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - pharmacology
Aspergillus
Aspergillus - chemistry
Aspergillus flavipes
Cell Line, Tumor
Cytotoxicity
Fermentation
fumiquinazoline-type alkaloid
Fungi
HL-60 Cells
Humans
Molecular Structure
OSMAC
Quinazolines - chemistry
Quinazolines - pharmacology
Tumor cell lines
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Summary:A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1), together with six known compounds (2-7), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was determined by the experimental and calculated ECD data. In addition, the cytotoxic activities against three human cancer cell lines (HL-60, THP-1, and PC-3) were evaluated.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2018.1463999