Stretchable and Photocatalytically Renewable Electrochemical Sensor Based on Sandwich Nanonetworks for Real-Time Monitoring of Cells

Stretchable electrochemical (EC) sensors have broad prospects in real-time monitoring of living cells and tissues owing to their excellent elasticity and deformability. However, the redox reaction products and cell secretions are easily adsorbed on the electrode, resulting in sensor fouling and pass...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2018-05, Vol.90 (10), p.5977-5981
Main Authors: Wang, Ya-Wen, Liu, Yan-Ling, Xu, Jia-Quan, Qin, Yu, Huang, Wei-Hua
Format: Article
Language:English
Subjects:
Analytical chemistry
Catalytic activity
Cells
Chemical sensors
Chemistry
Contaminants
Deformability
Deformation
Elasticity
Electrochemistry
Endothelial cells
Formability
Gold
Mast cells
Monitoring
Nanotechnology
Nanotubes
Nanowires
Organs
Performance degradation
Photocatalysis
Photodegradation
Pollution monitoring
Reaction products
Real time
Secretions
Sensors
Tissues
Titanium dioxide
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Summary:Stretchable electrochemical (EC) sensors have broad prospects in real-time monitoring of living cells and tissues owing to their excellent elasticity and deformability. However, the redox reaction products and cell secretions are easily adsorbed on the electrode, resulting in sensor fouling and passivation. Herein, we developed a stretchable and photocatalytically renewable EC sensor based on Au nanotubes (NTs) and TiO2 nanowires (NWs) sandwich nanonetworks. The external Au NTs are used for EC sensing, and internal TiO2 NWs provide photocatalytic performance to degrade contaminants, which endows the sensor with excellent EC performance, high photocatalytic activity, and favorable mechanical tensile property. This allows highly sensitive recycling monitoring of NO released from endothelial cells and 5-HT released from mast cells under their stretching states in real time, therefore providing a promising tool to unravel elastic and mechanically sensitive cells, tissues, and organs.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b01396