Recognition of cyclic‐di‐GMP by a riboswitch conducts translational repression through masking the ribosome‐binding site distant from the aptamer domain

The riboswitch is a class of RNA‐based gene regulatory machinery that is dependent on recognition of its target ligand by RNA tertiary structures. Ligand recognition is achieved by the aptamer domain, and ligand‐dependent structural changes of the expression platform then usually mediate termination...

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Bibliographic Details
Published in:Genes to cells : devoted to molecular & cellular mechanisms 2018-06, Vol.23 (6), p.435-447
Main Authors: Inuzuka, Saki, Kakizawa, Hitoshi, Nishimura, Kei‐ichiro, Naito, Takuto, Miyazaki, Katsushi, Furuta, Hiroyuki, Matsumura, Shigeyoshi, Ikawa, Yoshiya
Format: Article
Language:English
Subjects:
aptamer
Aptamers
Binding sites
c‐di‐GMP
Ligands
Nucleotides
Open reading frames
Ribonucleic acid
riboswitch
Riboswitches
RNA
Structure-function relationships
Transcription initiation
Transcription termination
Translation
Translation initiation
Translation termination
translational repression
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Summary:The riboswitch is a class of RNA‐based gene regulatory machinery that is dependent on recognition of its target ligand by RNA tertiary structures. Ligand recognition is achieved by the aptamer domain, and ligand‐dependent structural changes of the expression platform then usually mediate termination of transcription or translational initiation. Ligand‐dependent structural changes of the aptamer domain and expression platform have been reported for several riboswitches with short (
ISSN:1356-9597
1365-2443
DOI:10.1111/gtc.12586