The relationship between timing of prasugrel pretreatment and in-stent thrombus immediately after percutaneous coronary intervention for acute coronary syndrome: an optical coherence tomography study

• Published in: Heart and vessels 2018-10, Vol.33 (10), p.1159-1167
• Main Authors: Katayama, Yosuke, Kubo, Takashi, Ino, Yasushi, Kameyama, Takeyoshi, Matsuo, Yoshiki, Kitabata, Hironori, Terada, Kosei, Emori, Hiroki, Aoki, Hiroshi, Taruya, Akira, Shimamura, Kunihiro, Ota, Shingo, Tanaka, Atsushi, Hozumi, Takeshi, Akasaka, Takashi
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Angiography; Angioplasty; Biomedical Engineering and Bioengineering; Blood clots; Cardiac Surgery; Cardiology; Diagnosis; Diagnostic systems; Drug therapy; Implants; Intervention; Medical imaging; Medicine; Medicine & Public Health; Optical Coherence Tomography; Original Article; Stents; Surgical implants; Thrombosis; Tomography; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-018-1167-8

The optimal timing of pretreatment with prasugrel in percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) is unclear. We used optical coherence tomography (OCT) to compare in-stent thrombus volume immediately after PCI between the administration of low-dose prasugrel (20 mg loading dose) at the time of diagnosis of ACS (early prasugrel: n  = 34) and the administration of low-dose prasugrel immediately after diagnostic angiography prior to PCI for ACS (late prasugrel: n  = 56). The durations between the administration of prasugrel and OCT in the early prasugrel group and late prasugrel group were 5.1 ± 6.5 and 0.9 ± 0.7 h, respectively ( p