Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three‐dimensional networks with space negative charges, the ion flu...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-06, Vol.57 (26), p.7790-7794
Main Authors: Wu, Yafeng, Wang, Dianyu, Willner, Itamar, Tian, Ye, Jiang, Lei
Format: Article
Language:English
Subjects:
adjustable selective ion transport
Architecture
Crown ethers
Deoxyribonucleic acid
DNA
DNA hydrogels
Gating
high ion flux
Hydrogels
ion channels
Ion flux
Molecular chains
Peptides
Proteins
Switching theory
Transport
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Summary:Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three‐dimensional networks with space negative charges, the ion flux and rectification ratio are significantly enhanced. Upon cyclic treatment with K+ ions and crown ether, the DNA hydrogel states could be reversibly switched between less stiff and stiff networks, providing the gating mechanism of the nanochannel. Based on the architecture of DNA hydrogels and pH stimulus, cation or anion transport direction could be precisely controlled and multiple gating features are achieved. Meanwhile, G‐quadruplex DNA in the hydrogels might be replaced by other stimulus‐responsive DNA molecules, peptides, or proteins, and thus this work opens a new route for improving the functionalities of nanochannel by intelligent hydrogels. Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented. The DNA hydrogels are 3D networks with negative charges, switchable hydrogel states and pH responsiveness. High rectification ratios, high ion fluxes, controllable direction of cation or anion transport, and multiple gating features are exhibited for the nanochannels.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201803222