Association of diabetes mellitus with prostate cancer grade and prostate-specific antigen in Chinese biopsy population

•Diabetes was associated with a higher risk of PCa detection.•As diabetic duration and HbA1c increase, high-grade PCa risk was increased.•Diabetics had a 22.8% lower geometric mean PSA level than non-diabetics.•Low PSA levels in diabetics might delay and/or interfere with PCa detection. To investiga...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2018-07, Vol.141, p.80-87
Main Authors: Chen, Ming, Luo, Yili, Yang, Shaoling, Xu, Lu, Li, Nan, Li, Hong, Qu, Shen
Format: Article
Language:English
Subjects:
Diabetes mellitus
Grade
High-risk
Prostate cancer
Prostate-specific antigen
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Summary:•Diabetes was associated with a higher risk of PCa detection.•As diabetic duration and HbA1c increase, high-grade PCa risk was increased.•Diabetics had a 22.8% lower geometric mean PSA level than non-diabetics.•Low PSA levels in diabetics might delay and/or interfere with PCa detection. To investigate the association of diabetes mellitus with prostate cancer (PCa) grade and prostate-specific antigen (PSA) in Chinese biopsy population. We retrospectively evaluated data from 2032 patients who underwent prostate biopsies from 2010 to 2016 at our hospital. All diabetes cases were divided into sub-groups according to HbA1c (10 years). Among 2032 men, 467 (23.0%) were diabetic and 674 (33.2%) were diagnosed with PCa. Diabetes increased the overall risk of PCa (OR = 1.51, 95%CI: 1.12–2.05, P = 0.007), especially high-grade PCa (OR = 2.30, 95%CI: 1.47–3.61, P 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2018.04.022