Serum chloride as a novel marker for adding prognostic information of mortality in chronic heart failure

Serum chloride concentrations have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF). This study sought to investigate the prognostic ability of admission serum chloride for long...

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Bibliographic Details
Published in:Clinica chimica acta 2018-08, Vol.483, p.112-118
Main Authors: Zhang, Yang, Peng, Rui, Li, Xinqiang, Yu, Jinxing, Chen, Xi, Zhou, Zhou
Format: Article
Language:English
Subjects:
Chronic heart failure
Mortality
Prognosis
Serum chloride
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Summary:Serum chloride concentrations have clinical significance in the prognosis of heart failure (HF). Little is known regarding the prognostic value of serum chloride in patients with chronic heart failure (CHF). This study sought to investigate the prognostic ability of admission serum chloride for long-term mortality in CHF patients. We identified 1021 consecutive patients diagnosed with CHF. Participants were followed up for all-cause mortality at 21 ± 9 months to establish the survival models and analyze the association between admission serum chloride concentrations and death risk. Of the 1021 patients, 905(88.6%) available cases were obtained. Admission serum chloride concentrations of patients were independently and inversely associated with long-term mortality (hazard ratio [HR]: 0.890; 95% CI: 0.863 to 0.918; p 
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2018.04.028