Blood lymphocyte proliferation reaction in autoimmune thyropathies

Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25-and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25-and CD120-presenting function of blood lymphocytes was revealed. The findings in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-09, Vol.146 (3), p.286-288
Main Authors: Urazova, O. I, Kravets, E. B, Nedosekova, Yu. V, Rogaleva, A. V, Kuznecova, V. N, Rumpel, O. A
Format: Article
Language:English
Subjects:
Adult
autoimmune thyroiditis
Biomedical and Life Sciences
Biomedicine
Cell Biology
diffuse toxic goiter
General Pathology and Pathophysiology
Goiter - blood
Graves Disease - blood
Humans
Interleukin-2 Receptor alpha Subunit - metabolism
Internal Medicine
Laboratory Medicine
Lymphocyte Activation - immunology
lymphocyte proliferation reaction
Middle Aged
Pathology
Receptors, Tumor Necrosis Factor - metabolism
Thyroiditis, Autoimmune - blood
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Summary:Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25-and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25-and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the course of autoimmune thyroiditis and diffuse toxic goiter is associated with increased levels of basal, mitogen-and cytokine-stimulated proliferation of blood lymphocytes, particularly pronounced in thyroiditis in the euthyrosis stage.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0278-0